Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2464046..2464572 | Replicon | chromosome |
| Accession | NZ_CP028740 | ||
| Organism | Escherichia coli strain A35 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | AOY88_RS12090 | Protein ID | WP_000323025.1 |
| Coordinates | 2464046..2464333 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | AOY88_RS12095 | Protein ID | WP_000534858.1 |
| Coordinates | 2464333..2464572 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AOY88_RS12040 (2459070) | 2459070..2459285 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| AOY88_RS12045 (2459505) | 2459505..2459675 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| AOY88_RS12050 (2460039) | 2460039..2460254 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| AOY88_RS12055 (2460555) | 2460555..2460767 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| AOY88_RS12060 (2460822) | 2460822..2460911 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| AOY88_RS12065 (2461189) | 2461189..2461941 | - | 753 | WP_001047135.1 | antitermination protein | - |
| AOY88_RS12070 (2461955) | 2461955..2463004 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| AOY88_RS12075 (2463006) | 2463006..2463284 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| AOY88_RS12080 (2463351) | 2463351..2463602 | - | 252 | WP_000980994.1 | protein Rem | - |
| AOY88_RS12085 (2463819) | 2463819..2463974 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| AOY88_RS12090 (2464046) | 2464046..2464333 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| AOY88_RS12095 (2464333) | 2464333..2464572 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| AOY88_RS12100 (2464597) | 2464597..2464902 | + | 306 | WP_071527819.1 | protein YdfV | - |
| AOY88_RS12105 (2465105) | 2465105..2465437 | + | 333 | WP_001317460.1 | FlxA-like family protein | - |
| AOY88_RS12110 (2465874) | 2465874..2466023 | - | 150 | WP_180302674.1 | protein YdfW | - |
| AOY88_RS12115 (2466096) | 2466096..2467193 | - | 1098 | Protein_2359 | ISNCY family transposase | - |
| AOY88_RS12120 (2467248) | 2467248..2467667 | - | 420 | WP_001151196.1 | DUF977 family protein | - |
| AOY88_RS12125 (2467708) | 2467708..2468673 | - | 966 | WP_240766879.1 | hypothetical protein | - |
| AOY88_RS12130 (2468654) | 2468654..2469175 | - | 522 | WP_000705349.1 | toxin YdaT family protein | - |
| AOY88_RS12135 (2469159) | 2469159..2469386 | - | 228 | WP_000476993.1 | Cro/CI family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2428483..2479899 | 51416 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T103290 WP_000323025.1 NZ_CP028740:c2464333-2464046 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T103290 NZ_CP028740:c2464333-2464046 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT103290 WP_000534858.1 NZ_CP028740:c2464572-2464333 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT103290 NZ_CP028740:c2464572-2464333 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|