Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4314486..4315321 Replicon chromosome
Accession NZ_CP028739
Organism Escherichia coli strain A36

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2H4TUZ7
Locus tag AOY89_RS20970 Protein ID WP_000854744.1
Coordinates 4314486..4314863 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3J1F1Y9
Locus tag AOY89_RS20975 Protein ID WP_063104706.1
Coordinates 4314953..4315321 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY89_RS20940 (4310145) 4310145..4311986 + 1842 WP_000437380.1 RNA polymerase sigma factor RpoD -
AOY89_RS20945 (4312056) 4312056..4312562 - 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
AOY89_RS20955 (4312862) 4312862..4313707 - 846 WP_000065753.1 DUF4942 domain-containing protein -
AOY89_RS20960 (4313792) 4313792..4313989 - 198 WP_000772034.1 DUF957 domain-containing protein -
AOY89_RS20965 (4314001) 4314001..4314489 - 489 WP_000777668.1 DUF5983 family protein -
AOY89_RS20970 (4314486) 4314486..4314863 - 378 WP_000854744.1 TA system toxin CbtA family protein Toxin
AOY89_RS20975 (4314953) 4314953..4315321 - 369 WP_063104706.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AOY89_RS20980 (4315371) 4315371..4316015 - 645 WP_240745558.1 antitoxin of toxin-antitoxin stability system -
AOY89_RS20985 (4316034) 4316034..4316255 - 222 WP_089570377.1 DUF987 domain-containing protein -
AOY89_RS20990 (4316324) 4316324..4316800 - 477 WP_001186727.1 RadC family protein -
AOY89_RS20995 (4316815) 4316815..4317279 - 465 WP_000131518.1 antirestriction protein -
AOY89_RS21000 (4317672) 4317672..4318373 + 702 WP_137432245.1 glyoxalase superfamily protein -
AOY89_RS21005 (4318473) 4318473..4318649 - 177 Protein_4109 IS200/IS605 family transposase -
AOY89_RS21010 (4318706) 4318706..4319524 - 819 WP_001234708.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14138.13 Da        Isoelectric Point: 8.5163

>T103275 WP_000854744.1 NZ_CP028739:c4314863-4314486 [Escherichia coli]
MKTLPDTHVREASRCSSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACSCSQLINSIDILRARRATGLMTRSHYRTVNNITRGKHPEAKR

Download         Length: 378 bp

>T103275 NZ_CP028739:c4314863-4314486 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCTCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTCGTTGAAAAATACGCCCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTAGCTGCTCTCAGTTAATCAACAGTATCGATATCCTCCGGGCCCGCCGGGCAACAGGTCTGATGACCCGCAG
CCACTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13571.25 Da        Isoelectric Point: 6.2044

>AT103275 WP_063104706.1 NZ_CP028739:c4315321-4314953 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPSTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPCHQHTVTLYARGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT103275 NZ_CP028739:c4315321-4314953 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACTCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCAGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCTGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCAGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2H4TUZ7

Antitoxin

Source ID Structure
AlphaFold DB A0A3J1F1Y9

References