Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4174514..4175312 Replicon chromosome
Accession NZ_CP028739
Organism Escherichia coli strain A36

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag AOY89_RS20310 Protein ID WP_106991977.1
Coordinates 4174935..4175312 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag AOY89_RS20305 Protein ID WP_106991978.1
Coordinates 4174514..4174888 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY89_RS20270 (4170163) 4170163..4171047 + 885 WP_106991981.1 50S ribosome-binding GTPase -
AOY89_RS20275 (4171167) 4171167..4171844 + 678 WP_106991980.1 hypothetical protein -
AOY89_RS20280 (4171850) 4171850..4172083 + 234 WP_053289528.1 DUF905 family protein -
AOY89_RS20285 (4172174) 4172174..4172992 + 819 WP_106991979.1 DUF932 domain-containing protein -
AOY89_RS20290 (4173084) 4173084..4173569 + 486 WP_001586019.1 antirestriction protein -
AOY89_RS20295 (4173585) 4173585..4174061 + 477 WP_123051798.1 RadC family protein -
AOY89_RS20300 (4174130) 4174130..4174351 + 222 WP_001552746.1 DUF987 domain-containing protein -
AOY89_RS20305 (4174514) 4174514..4174888 + 375 WP_106991978.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AOY89_RS20310 (4174935) 4174935..4175312 + 378 WP_106991977.1 TA system toxin CbtA family protein Toxin
AOY89_RS20315 (4175309) 4175309..4175797 + 489 WP_240745552.1 DUF5983 family protein -
AOY89_RS20320 (4175809) 4175809..4176006 + 198 WP_240745553.1 hypothetical protein -
AOY89_RS20325 (4176091) 4176091..4176933 + 843 WP_240745742.1 DUF4942 domain-containing protein -
AOY89_RS20330 (4177213) 4177213..4177749 - 537 WP_000942821.1 GspM family type II secretion system protein YghD -
AOY89_RS20335 (4177751) 4177751..4178929 - 1179 WP_000097216.1 type II secretion system protein GspL -
AOY89_RS20340 (4178926) 4178926..4179903 - 978 WP_000633183.1 type II secretion system minor pseudopilin GspK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14178.13 Da        Isoelectric Point: 7.8045

>T103274 WP_106991977.1 NZ_CP028739:4174935-4175312 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALIRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T103274 NZ_CP028739:4174935-4175312 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGATACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAACATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13784.59 Da        Isoelectric Point: 6.5924

>AT103274 WP_106991978.1 NZ_CP028739:4174514-4174888 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNHLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT103274 NZ_CP028739:4174514-4174888 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCACCTGCATTACCTTGCCGACCGCGCGGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References