Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1088639..1089446 | Replicon | chromosome |
| Accession | NZ_CP028739 | ||
| Organism | Escherichia coli strain A36 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A8E2S9W0 |
| Locus tag | AOY89_RS05240 | Protein ID | WP_042004473.1 |
| Coordinates | 1088639..1089025 (-) | Length | 129 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A0P7R0L9 |
| Locus tag | AOY89_RS05245 | Protein ID | WP_001285482.1 |
| Coordinates | 1089072..1089446 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AOY89_RS05210 (1084437) | 1084437..1084631 | - | 195 | WP_001313570.1 | DUF957 domain-containing protein | - |
| AOY89_RS05215 (1084673) | 1084673..1084964 | + | 292 | Protein_1002 | transposase | - |
| AOY89_RS05220 (1084961) | 1084961..1085311 | + | 351 | WP_000624707.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| AOY89_RS05225 (1085342) | 1085342..1086935 | + | 1594 | Protein_1004 | IS66 family transposase | - |
| AOY89_RS05230 (1087083) | 1087083..1088071 | + | 989 | Protein_1005 | IS630 family transposase | - |
| AOY89_RS05235 (1088150) | 1088150..1088642 | - | 493 | Protein_1006 | DUF5983 family protein | - |
| AOY89_RS05240 (1088639) | 1088639..1089025 | - | 387 | WP_042004473.1 | TA system toxin CbtA family protein | Toxin |
| AOY89_RS05245 (1089072) | 1089072..1089446 | - | 375 | WP_001285482.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| AOY89_RS05250 (1089496) | 1089496..1090140 | - | 645 | WP_000086759.1 | hypothetical protein | - |
| AOY89_RS05255 (1090159) | 1090159..1090380 | - | 222 | WP_000692315.1 | DUF987 domain-containing protein | - |
| AOY89_RS05260 (1090443) | 1090443..1090919 | - | 477 | WP_001313574.1 | RadC family protein | - |
| AOY89_RS05265 (1090935) | 1090935..1091408 | - | 474 | WP_001313575.1 | antirestriction protein | - |
| AOY89_RS05270 (1091502) | 1091502..1091747 | - | 246 | WP_001164966.1 | hypothetical protein | - |
| AOY89_RS05275 (1091747) | 1091747..1092568 | - | 822 | WP_085432269.1 | DUF932 domain-containing protein | - |
| AOY89_RS05280 (1092668) | 1092668..1092901 | - | 234 | WP_097732417.1 | DUF905 family protein | - |
| AOY89_RS05285 (1093019) | 1093019..1093471 | - | 453 | WP_000682723.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 129 a.a. Molecular weight: 14595.66 Da Isoelectric Point: 8.2918
>T103258 WP_042004473.1 NZ_CP028739:c1089025-1088639 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRARRATGLMTRSNYRMVNDIIRGEHSEAKR
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRARRATGLMTRSNYRMVNDIIRGEHSEAKR
Download Length: 387 bp
>T103258 NZ_CP028739:c1089025-1088639 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCTTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCCCGCCGGGCAACCGGCCTGAT
GACCCGCAGCAACTACAGAATGGTGAACGACATCATCCGGGGTGAACATTCGGAGGCGAAACGATGA
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCTTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCCCGCCGGGCAACCGGCCTGAT
GACCCGCAGCAACTACAGAATGGTGAACGACATCATCCGGGGTGAACATTCGGAGGCGAAACGATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13791.44 Da Isoelectric Point: 4.7511
>AT103258 WP_001285482.1 NZ_CP028739:c1089446-1089072 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS
Download Length: 375 bp
>AT103258 NZ_CP028739:c1089446-1089072 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|