Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4427310..4427807 Replicon chromosome
Accession NZ_CP028738
Organism Escherichia coli strain A38

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag AOY91_RS21565 Protein ID WP_001173343.1
Coordinates 4427310..4427483 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag AOY91_RS21570 Protein ID WP_000398619.1
Coordinates 4427511..4427807 (-) Length 99 a.a.

Genomic Context

AOY91_RS21555AOY91_RS21560AOY91_RS21585AOY91_RS21590AOY91_RS21565AOY91_RS21570AOY91_RS21575AOY91_RS21580
Location: 4423980..4425437 (1458 bp)
Type: Others
Protein ID: WP_000856829.1
Location: 4425674..4427191 (1518 bp)
Type: Others
Protein ID: WP_001295074.1
Location: 4428729..4430360 (1632 bp)
Type: Others
Protein ID: WP_001216461.1
Location: 4430357..4431076 (720 bp)
Type: Others
Protein ID: WP_000611288.1
Location: 4427310..4427483 (174 bp)
Type: Toxin
Protein ID: WP_001173343.1
Location: 4427511..4427807 (297 bp)
Type: Antitoxin
Protein ID: WP_000398619.1
Location: 4428034..4428306 (273 bp)
Type: Others
Protein ID: WP_000405647.1
Location: 4428318..4428548 (231 bp)
Type: Others
Protein ID: WP_000371698.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AOY91_RS21555 (4423980)4423980..4425437+1458WP_000856829.1dipeptide/tripeptide permease DtpC-
AOY91_RS21560 (4425674)4425674..4427191+1518WP_001295074.1lysine--tRNA ligase-
AOY91_RS21565 (4427310)4427310..4427483-174WP_001173343.1type V toxin-antitoxin system toxin GhoTToxin
AOY91_RS21570 (4427511)4427511..4427807-297WP_000398619.1type V toxin-antitoxin system endoribonuclease antitoxin GhoSAntitoxin
AOY91_RS21575 (4428034)4428034..4428306-273WP_000405647.1GNAT family N-acetyltransferase-
AOY91_RS21580 (4428318)4428318..4428548-231WP_000371698.14Fe-4S mono-cluster protein YjdI-
AOY91_RS21585 (4428729)4428729..4430360+1632WP_001216461.1sensor histidine kinase-
AOY91_RS21590 (4430357)4430357..4431076+720WP_000611288.1two-component system response regulator DcuR-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T103252 WP_001173343.1 NZ_CP028738:c4427483-4427310 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T103252 NZ_CP028738:c4427483-4427310 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT103252 WP_000398619.1 NZ_CP028738:c4427807-4427511 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT103252 NZ_CP028738:c4427807-4427511 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CTTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7U9QI41

Antitoxin

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Source
ID
Structure
PDB2LLZ
AlphaFold DBA0A7U9QBH6

References