103233

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1374641..1375266 Replicon chromosome
Accession NZ_CP028738
Organism Escherichia coli strain A38

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AOY91_RS06705 Protein ID WP_000911330.1
Coordinates 1374868..1375266 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag AOY91_RS06700 Protein ID WP_000450524.1
Coordinates 1374641..1374868 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY91_RS06675 (1370444) 1370444..1370914 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
AOY91_RS06680 (1370914) 1370914..1371486 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
AOY91_RS06685 (1371632) 1371632..1372510 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
AOY91_RS06690 (1372527) 1372527..1373561 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
AOY91_RS06695 (1373774) 1373774..1374487 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
AOY91_RS06700 (1374641) 1374641..1374868 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
AOY91_RS06705 (1374868) 1374868..1375266 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
AOY91_RS06710 (1375413) 1375413..1376276 + 864 WP_001267508.1 neutral zinc metallopeptidase -
AOY91_RS06715 (1376291) 1376291..1378306 + 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
AOY91_RS06720 (1378380) 1378380..1379078 + 699 WP_000679823.1 esterase -
AOY91_RS06725 (1379188) 1379188..1379388 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T103233 WP_000911330.1 NZ_CP028738:1374868-1375266 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T103233 NZ_CP028738:1374868-1375266 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT103233 WP_000450524.1 NZ_CP028738:1374641-1374868 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT103233 NZ_CP028738:1374641-1374868 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References