Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3758355..3759156 Replicon chromosome
Accession NZ_CP028737
Organism Escherichia coli strain A39

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag AOY92_RS18120 Protein ID WP_107183515.1
Coordinates 3758779..3759156 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag AOY92_RS18115 Protein ID WP_240757873.1
Coordinates 3758355..3758729 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY92_RS18065 (3753374) 3753374..3753589 + 216 WP_087613786.1 transposase -
AOY92_RS18070 (3753737) 3753737..3754147 + 411 WP_087613785.1 hypothetical protein -
AOY92_RS18075 (3754211) 3754211..3754735 + 525 WP_240757869.1 hypothetical protein -
AOY92_RS18080 (3754726) 3754726..3755049 + 324 WP_240757870.1 hypothetical protein -
AOY92_RS18085 (3755237) 3755237..3756054 + 818 Protein_3546 DUF932 domain-containing protein -
AOY92_RS18090 (3756054) 3756054..3756227 + 174 WP_001183321.1 hypothetical protein -
AOY92_RS18095 (3756393) 3756393..3756866 + 474 WP_240757871.1 antirestriction protein -
AOY92_RS18100 (3756882) 3756882..3757358 + 477 WP_240757853.1 RadC family protein -
AOY92_RS18105 (3757421) 3757421..3757642 + 222 WP_000692323.1 DUF987 domain-containing protein -
AOY92_RS18110 (3757661) 3757661..3758305 + 645 WP_213836219.1 antitoxin of toxin-antitoxin stability system -
AOY92_RS18115 (3758355) 3758355..3758729 + 375 WP_240757873.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AOY92_RS18120 (3758779) 3758779..3759156 + 378 WP_107183515.1 TA system toxin CbtA family protein Toxin
AOY92_RS18125 (3759153) 3759153..3759645 + 493 Protein_3554 DUF5983 family protein -
AOY92_RS18130 (3759657) 3759657..3759806 + 150 Protein_3555 hypothetical protein -
AOY92_RS18135 (3759941) 3759941..3760762 + 822 Protein_3556 DUF4942 domain-containing protein -
AOY92_RS18145 (3761134) 3761134..3761865 - 732 WP_001301976.1 DNA polymerase III subunit epsilon -
AOY92_RS18150 (3761930) 3761930..3762397 + 468 WP_000917883.1 ribonuclease HI -
AOY92_RS18155 (3762394) 3762394..3763116 - 723 WP_240757874.1 class I SAM-dependent methyltransferase -
AOY92_RS18160 (3763150) 3763150..3763905 + 756 WP_021578376.1 hydroxyacylglutathione hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3750876..3763905 13029


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(17-116)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14120.28 Da        Isoelectric Point: 7.9086

>T103224 WP_107183515.1 NZ_CP028737:3758779-3759156 [Escherichia coli]
MKTLPVLPGQAVSSRPSPVEIWQALLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALMRTDQLGF
SICTHSQLINSIDILRARRATGLMTRSNYRMVNDIIRGKHSEAKR

Download         Length: 378 bp

>T103224 NZ_CP028737:3758779-3759156 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGTCAGTTCACGCCCATCTCCGGTTGAAATCTGGCAGGCACTGCTGAC
CCAGCTACTGGACCAGCATTACGGCCTCACTCTGAATGACACACCATTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATATGCGCTGATGCGTACCGACCAGCTGGGATTC
AGCATCTGTACCCACTCTCAGTTAATAAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCATCCGGGGTAAACATTCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13956.61 Da        Isoelectric Point: 6.4858

>AT103224 WP_240757873.1 NZ_CP028737:3758355-3758729 [Escherichia coli]
VSDTHHETTHPDDNNHPWWGMPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHLDQAFPLLIKQLELMLTSGE
LNPRHQHTVTLYAKGLTCHADTHGSCGYVYMAVYPTPETPATTE

Download         Length: 375 bp

>AT103224 NZ_CP028737:3758355-3758729 [Escherichia coli]
GTGTCAGACACGCACCATGAGACAACTCATCCCGATGACAACAACCACCCCTGGTGGGGGATGCCCTGCACCGTGACGCC
CTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGTTCA
GGGACGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATAAAACAACTGGAATTAATGCTCACCAGCGGTGAA
CTGAATCCCCGTCATCAGCATACTGTCACGCTGTATGCAAAAGGACTGACCTGCCATGCGGACACTCACGGCAGTTGTGG
TTACGTTTATATGGCTGTTTATCCGACACCGGAAACTCCCGCAACAACAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References