Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4249406..4250241 | Replicon | chromosome |
| Accession | NZ_CP028735 | ||
| Organism | Escherichia coli strain A41 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | AOY94_RS20620 | Protein ID | WP_240764435.1 |
| Coordinates | 4249864..4250241 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | AOY94_RS20615 | Protein ID | WP_096845217.1 |
| Coordinates | 4249406..4249774 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AOY94_RS20590 (4246847) | 4246847..4247060 | + | 214 | Protein_4027 | DUF905 family protein | - |
| AOY94_RS20595 (4247151) | 4247151..4247969 | + | 819 | WP_240764433.1 | DUF932 domain-containing protein | - |
| AOY94_RS20600 (4248061) | 4248061..4248546 | + | 486 | WP_053289216.1 | antirestriction protein | - |
| AOY94_RS20605 (4248562) | 4248562..4249038 | + | 477 | WP_240764434.1 | RadC family protein | - |
| AOY94_RS20610 (4249106) | 4249106..4249327 | + | 222 | WP_000692300.1 | DUF987 domain-containing protein | - |
| AOY94_RS20615 (4249406) | 4249406..4249774 | + | 369 | WP_096845217.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| AOY94_RS20620 (4249864) | 4249864..4250241 | + | 378 | WP_240764435.1 | TA system toxin CbtA family protein | Toxin |
| AOY94_RS20625 (4250238) | 4250238..4250435 | + | 198 | Protein_4034 | DUF5983 family protein | - |
| AOY94_RS20630 (4250463) | 4250463..4250660 | + | 198 | WP_105198716.1 | DUF957 domain-containing protein | - |
| AOY94_RS20635 (4250757) | 4250757..4251599 | + | 843 | WP_240764436.1 | DUF4942 domain-containing protein | - |
| AOY94_RS20640 (4251880) | 4251880..4252416 | - | 537 | WP_000942795.1 | GspM family type II secretion system protein YghD | - |
| AOY94_RS20645 (4252418) | 4252418..4253596 | - | 1179 | WP_000094971.1 | type II secretion system protein GspL | - |
| AOY94_RS20650 (4253593) | 4253593..4254570 | - | 978 | WP_000633238.1 | type II secretion system minor pseudopilin GspK | - |
| AOY94_RS20655 (4254573) | 4254573..4255172 | - | 600 | WP_001255040.1 | type II secretion system minor pseudopilin GspJ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | tssG / tssF / icmF/tssM / KPHS_23120 / tle1 / tli1 / vgrG/tssI / clpV/tssH / hcp/tssD / dotU/tssL / vasE/tssK / vipB/tssC / vipA/tssB / faeJ / faeI / faeH / faeG / faeF / faeE / faeD / faeC / gspM / gspL / gspK / gspJ / gspI / gspH / gspG / gspF / gspE / gspD / gspC | 4147985..4311359 | 163374 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14169.03 Da Isoelectric Point: 6.4806
>T103202 WP_240764435.1 NZ_CP028735:4249864-4250241 [Escherichia coli]
MNTLPDTHVREASHCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILQARRATDLMTRDNYRTVNNITLGKHPEAKR
MNTLPDTHVREASHCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILQARRATDLMTRDNYRTVNNITLGKHPEAKR
Download Length: 378 bp
>T103202 NZ_CP028735:4249864-4250241 [Escherichia coli]
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCATTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTTGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGTATCGATATCCTCCAGGCTCGTCGGGCGACCGACCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCAGAGGCGAAACGATGA
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCATTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTTGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGTATCGATATCCTCCAGGCTCGTCGGGCGACCGACCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCAGAGGCGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13607.37 Da Isoelectric Point: 6.6252
>AT103202 WP_096845217.1 NZ_CP028735:4249406-4249774 [Escherichia coli]
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT103202 NZ_CP028735:4249406-4249774 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|