103199

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3566767..3567392 Replicon chromosome
Accession NZ_CP028735
Organism Escherichia coli strain A41

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag AOY94_RS17175 Protein ID WP_000911329.1
Coordinates 3566767..3567165 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag AOY94_RS17180 Protein ID WP_000450524.1
Coordinates 3567165..3567392 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY94_RS17155 (3562645) 3562645..3562845 + 201 WP_000383836.1 YpfN family protein -
AOY94_RS17160 (3562955) 3562955..3563653 - 699 WP_000679823.1 esterase -
AOY94_RS17165 (3563727) 3563727..3565742 - 2016 WP_240764343.1 tRNA cytosine(34) acetyltransferase TmcA -
AOY94_RS17170 (3565757) 3565757..3566620 - 864 Protein_3356 neutral zinc metallopeptidase -
AOY94_RS17175 (3566767) 3566767..3567165 - 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
AOY94_RS17180 (3567165) 3567165..3567392 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
AOY94_RS17185 (3567547) 3567547..3568260 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
AOY94_RS17190 (3568473) 3568473..3569507 - 1035 WP_001440783.1 outer membrane protein assembly factor BamC -
AOY94_RS17195 (3569524) 3569524..3570402 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
AOY94_RS17200 (3570548) 3570548..3571120 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
AOY94_RS17205 (3571120) 3571120..3571590 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T103199 WP_000911329.1 NZ_CP028735:c3567165-3566767 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T103199 NZ_CP028735:c3567165-3566767 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT103199 WP_000450524.1 NZ_CP028735:c3567392-3567165 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT103199 NZ_CP028735:c3567392-3567165 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References