Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2543149..2543675 | Replicon | chromosome |
| Accession | NZ_CP028732 | ||
| Organism | Escherichia coli strain H3 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | AOY60_RS12365 | Protein ID | WP_000323025.1 |
| Coordinates | 2543149..2543436 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | AOY60_RS12370 | Protein ID | WP_000534858.1 |
| Coordinates | 2543436..2543675 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AOY60_RS12315 (2538173) | 2538173..2538388 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| AOY60_RS12320 (2538608) | 2538608..2538778 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| AOY60_RS12325 (2539142) | 2539142..2539357 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| AOY60_RS12330 (2539658) | 2539658..2539870 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| AOY60_RS12335 (2539925) | 2539925..2540014 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| AOY60_RS12340 (2540292) | 2540292..2541044 | - | 753 | WP_001047135.1 | antitermination protein | - |
| AOY60_RS12345 (2541058) | 2541058..2542107 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| AOY60_RS12350 (2542109) | 2542109..2542387 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| AOY60_RS12355 (2542454) | 2542454..2542705 | - | 252 | WP_000980994.1 | protein Rem | - |
| AOY60_RS12360 (2542922) | 2542922..2543077 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| AOY60_RS12365 (2543149) | 2543149..2543436 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| AOY60_RS12370 (2543436) | 2543436..2543675 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| AOY60_RS12375 (2543700) | 2543700..2544005 | + | 306 | WP_001326990.1 | protein YdfV | - |
| AOY60_RS12380 (2544208) | 2544208..2544540 | + | 333 | WP_001301033.1 | FlxA-like family protein | - |
| AOY60_RS12385 (2544977) | 2544977..2545126 | - | 150 | WP_011443592.1 | protein YdfW | - |
| AOY60_RS12390 (2545199) | 2545199..2546269 | - | 1071 | Protein_2417 | ISNCY family transposase | - |
| AOY60_RS12395 (2547059) | 2547059..2547346 | - | 288 | Protein_2418 | hypothetical protein | - |
| AOY60_RS12400 (2547824) | 2547824..2548313 | - | 490 | Protein_2419 | class I SAM-dependent methyltransferase | - |
| AOY60_RS12405 (2548310) | 2548310..2548561 | - | 252 | Protein_2420 | DUF977 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2529183..2557472 | 28289 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T103110 WP_000323025.1 NZ_CP028732:c2543436-2543149 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T103110 NZ_CP028732:c2543436-2543149 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT103110 WP_000534858.1 NZ_CP028732:c2543675-2543436 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT103110 NZ_CP028732:c2543675-2543436 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|