Detailed information of TA system TA103099

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 3503801..3504454
• Replicon: chromosome
• Accession: NZ_CP028731
• Organism: Mycobacterium avium strain HJW

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: DBO90_RS16310
• Protein ID: WP_009975163.1
• Coordinates: 3503801..3504262 (-)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: Q742J1
• Locus tag: DBO90_RS16315
• Protein ID: WP_003872881.1
• Coordinates: 3504266..3504454 (-)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DBO90_RS16295	3500293..3500679	-	387	WP_009975165.1	hypothetical protein	-
DBO90_RS16300	3500719..3502302	-	1584	WP_003872878.1	DUF4185 domain-containing protein	-
DBO90_RS16305	3503298..3503732	-	435	WP_023880080.1	hypothetical protein	-
DBO90_RS16310	3503801..3504262	-	462	WP_009975163.1	SRPBCC family protein	Toxin
DBO90_RS16315	3504266..3504454	-	189	WP_003872881.1	antitoxin	Antitoxin
DBO90_RS16320	3504516..3506888	-	2373	WP_009975162.1	cation-translocating P-type ATPase	-
DBO90_RS16325	3506885..3508471	-	1587	WP_009975161.1	serine hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (2-142)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-51)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 16627.13 Da
• Isoelectric Point: 9.5654

>T103099 WP_009975163.1 NZ_CP028731:c3504262-3503801 [Mycobacterium avium]
VAKLSGSIDVPLPPEVAWQHASDLSRYKEWLTIHRVWRSTLPDQNDKGTVVESIVEVKGMLNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLMAKVQPKADGSVVSFDVHLGGPALFGPIGMIVAAALRGDIDQSLENFVTVFARSDPSTNGHR

Nucleotide

• Length: 462 bp

>T103099 NZ_CP028731:c3504262-3503801 [Mycobacterium avium]
GTGGCCAAGCTATCCGGATCCATCGATGTCCCGCTGCCCCCCGAGGTGGCCTGGCAGCACGCCTCCGACCTGTCCCGGTA
CAAGGAGTGGCTGACCATTCACCGGGTGTGGCGCAGCACCTTGCCCGACCAGAACGACAAGGGCACCGTCGTCGAGTCGA
TCGTCGAGGTCAAGGGCATGCTCAACCGGATCAAATGGACGGTGGTGCGCTACAAGCCACCGGAGGGCATGACGCTCAAC
GGCGACGGCGTCGGCGGGGTCAAGGTCAAGCTGATGGCCAAGGTGCAGCCCAAGGCGGACGGTTCCGTCGTCAGCTTCGA
CGTGCACCTCGGCGGTCCGGCGCTGTTCGGGCCCATCGGCATGATCGTCGCGGCCGCGCTGCGCGGCGACATCGACCAGT
CGCTGGAGAACTTCGTCACGGTGTTCGCCCGATCGGATCCGAGCACCAACGGTCATCGCTGA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6745.42 Da
• Isoelectric Point: 4.4865

>AT103099 WP_003872881.1 NZ_CP028731:c3504454-3504266 [Mycobacterium avium]
MGFLDKAKDLLSQNADKVEMAIDKAGEFVDEKTQGKYSDTIHQVQEQAKKATGATETGDQQG

Nucleotide

• Length: 189 bp

>AT103099 NZ_CP028731:c3504454-3504266 [Mycobacterium avium]
ATGGGATTCCTGGACAAGGCCAAGGACCTGTTGTCGCAGAACGCCGACAAGGTCGAGATGGCCATCGACAAGGCCGGCGA
GTTCGTCGACGAGAAGACGCAGGGCAAGTACTCCGACACCATCCACCAGGTGCAGGAGCAGGCCAAGAAGGCCACCGGCG
CCACCGAGACCGGCGACCAGCAGGGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0E2WC18