Detailed information of TA system TA103098

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 3278818..3279382
• Replicon: chromosome
• Accession: NZ_CP028731
• Organism: Mycobacterium avium strain HJW

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: X7VBD8
• Locus tag: DBO90_RS15255
• Protein ID: WP_003875391.1
• Coordinates: 3278818..3279189 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DBO90_RS15260
• Protein ID: WP_011724021.1
• Coordinates: 3279176..3279382 (-)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DBO90_RS15215	3273984..3274307	-	324	WP_009975396.1	antibiotic biosynthesis monooxygenase	-
DBO90_RS15220	3274718..3275242	-	525	WP_033713819.1	glycoside hydrolase	-
DBO90_RS15225	3275399..3275752	-	354	WP_003875396.1	hypothetical protein	-
DBO90_RS15230	3275822..3276205	-	384	WP_023884114.1	hypothetical protein	-
DBO90_RS15235	3276274..3276672	-	399	WP_009975395.1	VOC family protein	-
DBO90_RS15240	3276774..3277379	-	606	WP_009975394.1	TetR/AcrR family transcriptional regulator; helix-turn-helix transcriptional regulator	-
DBO90_RS15245	3277475..3278212	+	738	WP_009975393.1	SDR family oxidoreductase	-
DBO90_RS15250	3278278..3278718	-	441	WP_003875392.1	nitroreductase family deazaflavin-dependent oxidoreductase	-
DBO90_RS15255	3278818..3279189	-	372	WP_003875391.1	type II toxin-antitoxin system VapC family toxin	Toxin
DBO90_RS15260	3279176..3279382	-	207	WP_011724021.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
DBO90_RS15265	3279551..3280495	-	945	WP_003875389.1	HNH endonuclease	-
DBO90_RS15270	3280695..3281768	-	1074	WP_009975391.1	redox-regulated ATPase YchF	-
DBO90_RS15275	3281899..3283092	+	1194	WP_080516334.1	hypothetical protein	-
DBO90_RS15280	3283109..3284107	-	999	WP_009975388.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13770.14 Da
• Isoelectric Point: 6.6003

>T103098 WP_003875391.1 NZ_CP028731:c3279189-3278818 [Mycobacterium avium]
MILVDTSVWIDHLHVADKRLIEFLTNDAIGCHQMVIEELALGAIRRRADLLRLLSNLRAFPLLTHAEVLHLVECHRLWGR
GLSAIDVHLLGSVALVDGARLWTRDKNLKAAGWDVGIAIVDEL

Nucleotide

• Length: 372 bp

>T103098 NZ_CP028731:c3279189-3278818 [Mycobacterium avium]
ATGATTCTCGTTGACACGTCGGTATGGATCGATCATCTGCACGTCGCCGACAAGCGACTCATAGAGTTCCTGACCAACGA
CGCAATCGGTTGCCACCAAATGGTGATCGAGGAGTTGGCATTGGGTGCGATCAGGCGGCGCGCCGATCTATTGCGCCTGC
TGTCCAATCTTCGGGCGTTCCCGTTGCTGACGCATGCGGAGGTCCTTCATCTCGTCGAATGCCACCGCTTGTGGGGCCGC
GGACTGAGTGCGATCGACGTCCATCTTCTCGGGTCGGTTGCTCTGGTCGACGGTGCACGGCTATGGACCAGGGACAAGAA
TTTAAAAGCGGCGGGCTGGGACGTGGGTATCGCGATCGTCGACGAGCTCTGA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7261.25 Da
• Isoelectric Point: 11.0634

>AT103098 WP_011724021.1 NZ_CP028731:c3279382-3279176 [Mycobacterium avium]
MRTTVTIDDALLAEAAELTGVTESVALLRQGLQTLVRVESARRLAALGGTDRKASVGPRRRTPADDSR

Nucleotide

• Length: 207 bp

>AT103098 NZ_CP028731:c3279382-3279176 [Mycobacterium avium]
ATGAGGACGACGGTGACGATTGACGACGCCTTATTGGCAGAGGCGGCCGAACTGACCGGGGTGACAGAGAGCGTGGCGCT
CCTCCGTCAGGGACTGCAGACACTCGTTCGGGTAGAGAGCGCCCGTCGGCTGGCGGCGCTCGGCGGCACGGATCGGAAGG
CATCGGTCGGCCCTCGCCGGAGGACACCCGCCGATGATTCTCGTTGA

Structures

Toxin

• AlphaFold DB: A0A0E2WB37