Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-PHD |
Location | 2404051..2404712 | Replicon | chromosome |
Accession | NZ_CP028731 | ||
Organism | Mycobacterium avium strain HJW |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A049E7F1 |
Locus tag | DBO90_RS11375 | Protein ID | WP_023879930.1 |
Coordinates | 2404051..2404455 (-) | Length | 135 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A049EBE1 |
Locus tag | DBO90_RS11380 | Protein ID | WP_009976405.1 |
Coordinates | 2404452..2404712 (-) | Length | 87 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DBO90_RS11350 | 2399230..2400399 | + | 1170 | WP_009976416.1 | acyl-CoA dehydrogenase | - |
DBO90_RS11355 | 2400388..2400918 | - | 531 | WP_011724637.1 | TetR/AcrR family transcriptional regulator | - |
DBO90_RS11360 | 2401039..2401584 | - | 546 | WP_009976412.1 | carboxymuconolactone decarboxylase family protein | - |
DBO90_RS11365 | 2401581..2402102 | - | 522 | WP_009976411.1 | carboxymuconolactone decarboxylase family protein | - |
DBO90_RS11370 | 2402339..2403904 | + | 1566 | WP_029248458.1 | serine/threonine protein kinase | - |
DBO90_RS11375 | 2404051..2404455 | - | 405 | WP_023879930.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
DBO90_RS11380 | 2404452..2404712 | - | 261 | WP_009976405.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
DBO90_RS11385 | 2404893..2405345 | - | 453 | WP_029248457.1 | VOC family protein | - |
DBO90_RS11390 | 2405511..2406779 | + | 1269 | WP_121035778.1 | cytochrome P450 | - |
DBO90_RS11395 | 2406981..2408441 | - | 1461 | WP_009976402.1 | serine/threonine protein kinase | - |
DBO90_RS11400 | 2408636..2409298 | - | 663 | WP_009976400.1 | TetR/AcrR family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 135 a.a. Molecular weight: 14329.33 Da Isoelectric Point: 4.5860
>T103097 WP_023879930.1 NZ_CP028731:c2404455-2404051 [Mycobacterium avium]
MTARPAGVLDTSVFIASESGRHLDEARIPDEVATTVITLAELHAGVLAATTSDVRAQRLATLESIADMEMLPVDDDAARM
WARLRIHLAEAGRRMRANDLWIAGIAASRGLPVVTQDDDFAALDGAANLAIIRV
MTARPAGVLDTSVFIASESGRHLDEARIPDEVATTVITLAELHAGVLAATTSDVRAQRLATLESIADMEMLPVDDDAARM
WARLRIHLAEAGRRMRANDLWIAGIAASRGLPVVTQDDDFAALDGAANLAIIRV
Download Length: 405 bp
>T103097 NZ_CP028731:c2404455-2404051 [Mycobacterium avium]
ATGACTGCAAGGCCGGCCGGGGTGCTCGACACCTCGGTGTTCATCGCGTCCGAAAGCGGACGGCACCTGGACGAGGCGCG
AATCCCCGACGAGGTAGCCACCACCGTCATCACCCTTGCCGAACTTCACGCCGGCGTATTAGCCGCGACGACGTCCGACG
TTCGGGCGCAACGCCTCGCAACGCTGGAATCGATAGCGGATATGGAAATGTTGCCAGTCGACGACGACGCGGCCCGCATG
TGGGCAAGGTTGCGGATCCACCTAGCCGAGGCTGGACGGCGGATGCGGGCTAATGATCTGTGGATCGCGGGGATCGCGGC
ATCGCGGGGACTGCCCGTTGTCACCCAGGATGACGACTTCGCCGCACTCGACGGCGCGGCGAACCTGGCGATTATTCGGG
TTTGA
ATGACTGCAAGGCCGGCCGGGGTGCTCGACACCTCGGTGTTCATCGCGTCCGAAAGCGGACGGCACCTGGACGAGGCGCG
AATCCCCGACGAGGTAGCCACCACCGTCATCACCCTTGCCGAACTTCACGCCGGCGTATTAGCCGCGACGACGTCCGACG
TTCGGGCGCAACGCCTCGCAACGCTGGAATCGATAGCGGATATGGAAATGTTGCCAGTCGACGACGACGCGGCCCGCATG
TGGGCAAGGTTGCGGATCCACCTAGCCGAGGCTGGACGGCGGATGCGGGCTAATGATCTGTGGATCGCGGGGATCGCGGC
ATCGCGGGGACTGCCCGTTGTCACCCAGGATGACGACTTCGCCGCACTCGACGGCGCGGCGAACCTGGCGATTATTCGGG
TTTGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9495.81 Da Isoelectric Point: 11.4633
>AT103097 WP_009976405.1 NZ_CP028731:c2404712-2404452 [Mycobacterium avium]
MSEVASRELRNDTAGVLRRVREGEDVTITVNGRAVAMLTALGPQRRRWLSKAELLSRLRRAQADPGLRQDLATLAGDTTE
DLGPIR
MSEVASRELRNDTAGVLRRVREGEDVTITVNGRAVAMLTALGPQRRRWLSKAELLSRLRRAQADPGLRQDLATLAGDTTE
DLGPIR
Download Length: 261 bp
>AT103097 NZ_CP028731:c2404712-2404452 [Mycobacterium avium]
ATGTCTGAAGTGGCGTCTCGCGAGCTGCGCAACGATACGGCGGGGGTACTGCGGCGCGTGCGGGAAGGGGAGGACGTCAC
CATCACCGTCAACGGCCGAGCCGTCGCGATGCTGACCGCGCTGGGGCCGCAGCGACGGCGGTGGCTGAGCAAGGCGGAGT
TGCTGTCGCGCTTGCGCCGCGCGCAAGCCGATCCCGGGCTACGCCAAGACCTCGCAACCCTTGCAGGCGACACAACTGAG
GACCTCGGTCCGATCCGATGA
ATGTCTGAAGTGGCGTCTCGCGAGCTGCGCAACGATACGGCGGGGGTACTGCGGCGCGTGCGGGAAGGGGAGGACGTCAC
CATCACCGTCAACGGCCGAGCCGTCGCGATGCTGACCGCGCTGGGGCCGCAGCGACGGCGGTGGCTGAGCAAGGCGGAGT
TGCTGTCGCGCTTGCGCCGCGCGCAAGCCGATCCCGGGCTACGCCAAGACCTCGCAACCCTTGCAGGCGACACAACTGAG
GACCTCGGTCCGATCCGATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A049E7F1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A049EBE1 |