Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 2404051..2404712 Replicon chromosome
Accession NZ_CP028731
Organism Mycobacterium avium strain HJW

Toxin (Protein)


Gene name vapC Uniprot ID A0A049E7F1
Locus tag DBO90_RS11375 Protein ID WP_023879930.1
Coordinates 2404051..2404455 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A049EBE1
Locus tag DBO90_RS11380 Protein ID WP_009976405.1
Coordinates 2404452..2404712 (-) Length 87 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBO90_RS11350 2399230..2400399 + 1170 WP_009976416.1 acyl-CoA dehydrogenase -
DBO90_RS11355 2400388..2400918 - 531 WP_011724637.1 TetR/AcrR family transcriptional regulator -
DBO90_RS11360 2401039..2401584 - 546 WP_009976412.1 carboxymuconolactone decarboxylase family protein -
DBO90_RS11365 2401581..2402102 - 522 WP_009976411.1 carboxymuconolactone decarboxylase family protein -
DBO90_RS11370 2402339..2403904 + 1566 WP_029248458.1 serine/threonine protein kinase -
DBO90_RS11375 2404051..2404455 - 405 WP_023879930.1 type II toxin-antitoxin system VapC family toxin Toxin
DBO90_RS11380 2404452..2404712 - 261 WP_009976405.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DBO90_RS11385 2404893..2405345 - 453 WP_029248457.1 VOC family protein -
DBO90_RS11390 2405511..2406779 + 1269 WP_121035778.1 cytochrome P450 -
DBO90_RS11395 2406981..2408441 - 1461 WP_009976402.1 serine/threonine protein kinase -
DBO90_RS11400 2408636..2409298 - 663 WP_009976400.1 TetR/AcrR family transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-124)

Antitoxin

(1-64)


Sequences


Toxin        


Download         Length: 135 a.a.        Molecular weight: 14329.33 Da        Isoelectric Point: 4.5860

>T103097 WP_023879930.1 NZ_CP028731:c2404455-2404051 [Mycobacterium avium]
MTARPAGVLDTSVFIASESGRHLDEARIPDEVATTVITLAELHAGVLAATTSDVRAQRLATLESIADMEMLPVDDDAARM
WARLRIHLAEAGRRMRANDLWIAGIAASRGLPVVTQDDDFAALDGAANLAIIRV

Download         Length: 405 bp

>T103097 NZ_CP028731:c2404455-2404051 [Mycobacterium avium]
ATGACTGCAAGGCCGGCCGGGGTGCTCGACACCTCGGTGTTCATCGCGTCCGAAAGCGGACGGCACCTGGACGAGGCGCG
AATCCCCGACGAGGTAGCCACCACCGTCATCACCCTTGCCGAACTTCACGCCGGCGTATTAGCCGCGACGACGTCCGACG
TTCGGGCGCAACGCCTCGCAACGCTGGAATCGATAGCGGATATGGAAATGTTGCCAGTCGACGACGACGCGGCCCGCATG
TGGGCAAGGTTGCGGATCCACCTAGCCGAGGCTGGACGGCGGATGCGGGCTAATGATCTGTGGATCGCGGGGATCGCGGC
ATCGCGGGGACTGCCCGTTGTCACCCAGGATGACGACTTCGCCGCACTCGACGGCGCGGCGAACCTGGCGATTATTCGGG
TTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9495.81 Da        Isoelectric Point: 11.4633

>AT103097 WP_009976405.1 NZ_CP028731:c2404712-2404452 [Mycobacterium avium]
MSEVASRELRNDTAGVLRRVREGEDVTITVNGRAVAMLTALGPQRRRWLSKAELLSRLRRAQADPGLRQDLATLAGDTTE
DLGPIR

Download         Length: 261 bp

>AT103097 NZ_CP028731:c2404712-2404452 [Mycobacterium avium]
ATGTCTGAAGTGGCGTCTCGCGAGCTGCGCAACGATACGGCGGGGGTACTGCGGCGCGTGCGGGAAGGGGAGGACGTCAC
CATCACCGTCAACGGCCGAGCCGTCGCGATGCTGACCGCGCTGGGGCCGCAGCGACGGCGGTGGCTGAGCAAGGCGGAGT
TGCTGTCGCGCTTGCGCCGCGCGCAAGCCGATCCCGGGCTACGCCAAGACCTCGCAACCCTTGCAGGCGACACAACTGAG
GACCTCGGTCCGATCCGATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A049E7F1


Antitoxin

Source ID Structure
AlphaFold DB A0A049EBE1

References