Detailed information of TA system TA103096

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/ParD(antitoxin)
• Location: 1887716..1888714
• Replicon: chromosome
• Accession: NZ_CP028731
• Organism: Mycobacterium avium strain HJW

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: X7VT18
• Locus tag: DBO90_RS08880
• Protein ID: WP_003876749.1
• Coordinates: 1887716..1888294 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: A0A049EEK5
• Locus tag: DBO90_RS08885
• Protein ID: WP_009976725.1
• Coordinates: 1888325..1888714 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DBO90_RS08855	1883708..1884640	-	933	WP_009976731.1	sigma-70 family RNA polymerase sigma factor	-
DBO90_RS08860	1884809..1885159	+	351	WP_003878038.1	DoxX family protein	-
DBO90_RS08865	1885173..1885973	-	801	WP_009976729.1	nuclear transport factor 2 family protein	-
DBO90_RS08870	1885973..1886533	-	561	WP_155251422.1	pyrazinamidase PncA	-
DBO90_RS08875	1886644..1887711	+	1068	WP_003876748.1	DoxX family membrane protein	-
DBO90_RS08880	1887716..1888294	-	579	WP_003876749.1	zeta toxin family protein	Toxin
DBO90_RS08885	1888325..1888714	-	390	WP_009976725.1	hypothetical protein	Antitoxin
DBO90_RS08890	1888795..1889289	-	495	WP_009976723.1	gluconokinase	-
DBO90_RS08895	1889286..1891283	-	1998	WP_009976721.1	phosphotransferase	-
DBO90_RS08900	1891302..1892819	-	1518	WP_009976720.1	carboxylesterase/lipase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1893123..1894175	1052

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (5-136)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21034.18 Da
• Isoelectric Point: 10.6678

>T103096 WP_003876749.1 NZ_CP028731:c1888294-1887716 [Mycobacterium avium]
MERLDVVVGPNGAGKSTFIALTLAPLLPGSVVVNADEIARQRWPQDPASHAYDAAKVAADTRAKLIDLGRSFIAETVFSH
PSKLDLLHAARRAGFTVVLHVLLIPEDLAVERVRHRVRAGGHDVPETKIRERHRRLWTPVAEAMTLADLATGYDNSRLRG
PRVVARLSGGLTVGAVDWPAWAPETLRSRWPV

Nucleotide

• Length: 579 bp

>T103096 NZ_CP028731:c1888294-1887716 [Mycobacterium avium]
ATGGAGCGACTCGACGTGGTGGTCGGGCCCAACGGCGCCGGCAAGTCGACGTTCATCGCGTTGACCCTGGCGCCGCTGCT
GCCGGGCAGCGTGGTGGTCAACGCCGACGAGATCGCGCGGCAGCGCTGGCCGCAGGATCCGGCGTCGCACGCCTACGACG
CCGCGAAGGTCGCCGCCGACACCCGGGCGAAGCTGATCGACCTGGGCCGGTCGTTCATCGCCGAGACCGTGTTCTCCCAC
CCGTCCAAGCTGGACCTGCTGCACGCCGCCCGCCGCGCCGGCTTCACCGTCGTGCTGCACGTGCTGCTCATCCCGGAAGA
CCTTGCCGTCGAACGGGTCCGGCACCGCGTGCGGGCCGGCGGCCATGACGTGCCGGAAACCAAGATCCGCGAGCGGCATC
GCCGGTTGTGGACTCCGGTCGCCGAGGCGATGACCCTGGCCGACCTGGCCACCGGCTACGACAACAGCCGGCTGCGCGGG
CCGCGTGTGGTGGCCCGGCTCAGCGGCGGGCTGACGGTCGGTGCCGTCGACTGGCCGGCGTGGGCACCCGAGACCTTGCG
GTCGCGTTGGCCGGTCTAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13598.04 Da
• Isoelectric Point: 5.6717

>AT103096 WP_009976725.1 NZ_CP028731:c1888714-1888325 [Mycobacterium avium]
MAEAVDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGRLSTAELTVEEGVVFNAEI
SAAIDESLARTNYGATLAGQGVTTVALNDDGEIVEHRPDGTAVVLAGRR

Nucleotide

• Length: 390 bp

>AT103096 NZ_CP028731:c1888714-1888325 [Mycobacterium avium]
ATGGCCGAGGCCGTCGATCGGGTCACCCGGGTCGCGTCCGATCTGATGGACAGCGCGGCGGCCGAGGGCGCCCGTCAGAG
CCGCTCGGCCAAGCAGCAGCTCGACCACTGGGCGCGGGTCGGGCGTGCGGTGTCCAGCCAGCACACCGCGTCCCGGCGGC
GGGTCGAAGCCGCGCTGGCCGGCCGGCTGTCCACCGCCGAACTCACCGTCGAAGAGGGCGTGGTGTTCAACGCCGAGATC
TCGGCGGCCATCGACGAAAGCCTGGCGCGCACCAACTACGGGGCGACGCTGGCCGGGCAGGGTGTCACCACGGTGGCCCT
CAACGACGATGGCGAGATCGTCGAGCACCGGCCCGACGGCACCGCGGTGGTGCTGGCCGGCCGGCGCTGA

Structures

Toxin

• AlphaFold DB: A0A0E2W6B4

Antitoxin

• AlphaFold DB: A0A049EEK5