Detailed information of TA system TA103095

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ParE-CopA/ParE-RHH
• Location: 4387044..4387609
• Replicon: chromosome
• Accession: NZ_CP028730
• Organism: Shewanella baltica strain 128

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: C7T95_RS18985
• Protein ID: WP_107949552.1
• Coordinates: 4387316..4387609 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: copA
• Uniprot ID: A0A448EM94
• Locus tag: C7T95_RS18980
• Protein ID: WP_011716807.1
• Coordinates: 4387044..4387328 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7T95_RS18940	4382133..4382390	+	258	WP_199908765.1	hypothetical protein	-
C7T95_RS18945	4382910..4383107	-	198	WP_107950357.1	AlpA family transcriptional regulator	-
C7T95_RS18950	4383240..4383746	+	507	WP_159075009.1	DNA repair protein RadC	-
C7T95_RS18955	4383790..4384152	+	363	WP_107949544.1	hypothetical protein	-
C7T95_RS18960	4384277..4384657	+	381	WP_107949546.1	type IV toxin-antitoxin system YeeU family antitoxin	-
C7T95_RS18965	4384798..4385211	+	414	WP_107949548.1	DUF2787 domain-containing protein	-
C7T95_RS18970	4385334..4385894	+	561	WP_107950361.1	tyrosine-type recombinase/integrase	-
C7T95_RS18975	4386039..4386761	+	723	WP_107949550.1	lecithin retinol acyltransferase family protein	-
C7T95_RS18980	4387044..4387328	+	285	WP_011716807.1	CopG family ribbon-helix-helix protein	Antitoxin
C7T95_RS18985	4387316..4387609	+	294	WP_107949552.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C7T95_RS18990	4387785..4388453	-	669	WP_107949554.1	inovirus Gp2 family protein	-
C7T95_RS18995	4388856..4390190	-	1335	WP_107949556.1	hypothetical protein	-
C7T95_RS19000	4390422..4391141	+	720	WP_107949558.1	hypothetical protein	-
C7T95_RS19005	4391461..4391783	+	323	Protein_3594	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

• Ribbon-helix-helix protein, CopG (7-44)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11166.71 Da
• Isoelectric Point: 5.8404

>T103095 WP_107949552.1 NZ_CP028730:4387316-4387609 [Shewanella baltica]
MPQIIFTATALRDLERLREFLRSKNPPAAQRAASAIINTIRKLESYPDIGRPIDDNDFNFRELLIDFGDTGYLAMYQYDG
GERLTVLCIRHQKEAGY

Nucleotide

• Length: 294 bp

>T103095 NZ_CP028730:4387316-4387609 [Shewanella baltica]
ATGCCACAAATAATCTTCACTGCCACAGCATTACGTGATTTAGAGCGCTTACGTGAGTTTCTTCGCAGTAAAAATCCTCC
CGCCGCACAACGGGCTGCCAGCGCCATAATCAATACCATTAGAAAACTGGAAAGCTATCCAGATATTGGCCGGCCTATCG
ATGACAATGACTTCAATTTTAGGGAACTGCTTATCGATTTTGGTGACACTGGTTATTTGGCAATGTACCAGTATGATGGC
GGCGAACGATTGACAGTGTTGTGTATCCGCCACCAAAAAGAAGCCGGTTACTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10955.25 Da
• Isoelectric Point: 5.9920

>AT103095 WP_011716807.1 NZ_CP028730:4387044-4387328 [Shewanella baltica]
MSTIKPVSVKLDADIKARVEHLAETRKRSSHWMMREAIREYVEREEKREALQQEALRAWEEHQTSGLHVTGDEVVSWLES
WGSENEQAAPTCHK

Nucleotide

• Length: 285 bp

>AT103095 NZ_CP028730:4387044-4387328 [Shewanella baltica]
ATGAGCACAATCAAACCCGTGTCGGTTAAATTAGATGCCGATATTAAAGCCAGAGTCGAGCATTTAGCCGAAACGCGTAA
ACGTTCATCACACTGGATGATGCGTGAAGCGATCCGTGAATACGTTGAGAGAGAAGAGAAGCGCGAGGCGCTGCAGCAAG
AAGCGTTACGCGCATGGGAAGAACACCAGACATCTGGCTTGCACGTTACCGGTGACGAAGTGGTGAGTTGGCTAGAGTCC
TGGGGAAGTGAAAATGAACAGGCAGCCCCTACATGCCACAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A448EM94