Detailed information of TA system TA103092

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ParE-CopA/ParE-RHH
• Location: 2173079..2173644
• Replicon: chromosome
• Accession: NZ_CP028730
• Organism: Shewanella baltica strain 128

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: C7T95_RS09405
• Protein ID: WP_107947282.1
• Coordinates: 2173079..2173372 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: copA
• Uniprot ID: A0A448EM94
• Locus tag: C7T95_RS09410
• Protein ID: WP_011716807.1
• Coordinates: 2173360..2173644 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7T95_RS09385	2168925..2170070	+	1146	WP_107947273.1	hypothetical protein	-
C7T95_RS09390	2170210..2170422	+	213	WP_107947275.1	AlpA family phage regulatory protein	-
C7T95_RS09395	2170462..2171904	+	1443	WP_107947277.1	DUF3987 domain-containing protein	-
C7T95_RS09400	2172245..2172907	+	663	WP_107947279.1	inovirus Gp2 family protein	-
C7T95_RS09405	2173079..2173372	-	294	WP_107947282.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C7T95_RS09410	2173360..2173644	-	285	WP_011716807.1	CopG family ribbon-helix-helix protein	Antitoxin
C7T95_RS09415	2173931..2174653	-	723	WP_107947284.1	lecithin retinol acyltransferase family protein	-
C7T95_RS09420	2174742..2175308	-	567	WP_107947286.1	site-specific integrase	-
C7T95_RS09425	2175417..2175824	-	408	WP_107947288.1	DUF2787 domain-containing protein	-
C7T95_RS09435	2176018..2176431	-	414	WP_107947290.1	DUF2787 domain-containing protein	-
C7T95_RS09440	2176676..2177032	-	357	WP_107947292.1	type IV toxin-antitoxin system YeeU family antitoxin	-
C7T95_RS09445	2177172..2177534	-	363	WP_076500087.1	hypothetical protein	-
C7T95_RS09450	2177575..2178036	-	462	WP_107950206.1	DNA repair protein RadC	-
C7T95_RS09455	2178152..2178351	+	200	Protein_1801	AlpA family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

• Ribbon-helix-helix protein, CopG (7-44)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11152.68 Da
• Isoelectric Point: 5.8404

>T103092 WP_107947282.1 NZ_CP028730:c2173372-2173079 [Shewanella baltica]
MPQIIFTATALRDLERLREFLRSKNPPAAQRAASAIINTIRKLESYPDIGRPIDDNDFNFRELLIDFGDTGYLAMYQYDG
GERLTVLCVRHQKEAGY

Nucleotide

• Length: 294 bp

>T103092 NZ_CP028730:c2173372-2173079 [Shewanella baltica]
ATGCCACAAATAATCTTCACTGCCACAGCATTACGTGATTTAGAGCGCTTACGTGAGTTTCTTCGCAGTAAAAATCCTCC
CGCCGCACAACGGGCTGCCAGCGCCATAATCAATACCATTAGAAAACTGGAAAGCTATCCAGACATTGGCCGGCCTATCG
ATGACAATGACTTCAATTTTAGGGAACTGCTGATTGACTTTGGTGACACGGGTTATTTGGCAATGTACCAGTATGATGGC
GGCGAGCGATTGACCGTATTGTGTGTTCGACATCAAAAGGAAGCTGGCTATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10955.25 Da
• Isoelectric Point: 5.9920

>AT103092 WP_011716807.1 NZ_CP028730:c2173644-2173360 [Shewanella baltica]
MSTIKPVSVKLDADIKARVEHLAETRKRSSHWMMREAIREYVEREEKREALQQEALRAWEEHQTSGLHVTGDEVVSWLES
WGSENEQAAPTCHK

Nucleotide

• Length: 285 bp

>AT103092 NZ_CP028730:c2173644-2173360 [Shewanella baltica]
ATGAGCACAATCAAACCCGTGTCGGTAAAATTAGATGCCGATATTAAAGCCAGAGTCGAGCATTTAGCCGAAACCCGTAA
ACGTTCATCACACTGGATGATGCGTGAAGCGATCCGTGAATACGTTGAGAGAGAAGAGAAACGCGAGGCGTTGCAGCAAG
AAGCGTTACGCGCATGGGAAGAACACCAGACATCAGGCTTGCATGTCACCGGTGACGAAGTGGTGAGTTGGCTGGAGTCC
TGGGGAAGTGAAAATGAACAGGCAGCCCCTACATGCCACAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A448EM94