Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 725692..727233 Replicon chromosome
Accession NZ_CP028730
Organism Shewanella baltica strain 128

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag C7T95_RS02965 Protein ID WP_107946511.1
Coordinates 725932..727233 (+) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag C7T95_RS02960 Protein ID WP_107950115.1
Coordinates 725692..725928 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7T95_RS02940 720711..721712 + 1002 WP_107946510.1 LysR family transcriptional regulator -
C7T95_RS02945 721709..723070 - 1362 WP_106649376.1 MATE family efflux transporter -
C7T95_RS02950 723295..723585 + 291 WP_006086113.1 co-chaperone GroES -
C7T95_RS02955 723643..725280 + 1638 WP_106649377.1 chaperonin GroEL -
C7T95_RS02960 725692..725928 + 237 WP_107950115.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
C7T95_RS02965 725932..727233 + 1302 WP_107946511.1 HipA domain-containing protein Toxin
C7T95_RS02980 730004..730651 - 648 Protein_567 restriction endonuclease -
C7T95_RS02985 730843..731649 - 807 WP_107946512.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48717.94 Da        Isoelectric Point: 5.4810

>T103090 WP_107946511.1 NZ_CP028730:725932-727233 [Shewanella baltica]
MSTSKKLTLEMHLGDLMIGELSFDATTDTFAVHYTKDWQQSGFPLSPTIPLDGTGTSNQISMFLVNLLPENKGLDYLIES
LGVSKGNTFALIRAIGLDTAGAVAFVPKGTLLPETQLRPIKTEEVIQRIEDPTMWPMEIWDGKPRLSVAGVQPKLNLFYN
GKEFAFAEGVLSSTHIVKFEKYRHLVLNEFMTMRLAKAIGMNVANVDIVHFGDYKVLCVERFDRRYMPNEQRVLRRHIVD
SCQALGFSVSKKYERNFGSGRDVKDIREGVSFNRLFSLAAKCRNPVAAKQDMLQWALFNLLTGNADAHGKNYSFFMTPSG
MEPTPWYDLVSVAMYEDFEQQLAMAIDDEFDPNSIYAYQLAAFIDGLGLPRNLLISNLTTIARRIPQAIDGVISMLPPLD
EDEASFVAHYKAQLLARCDRYFSFAADVRDVEV

Download         Length: 1302 bp

>T103090 NZ_CP028730:725932-727233 [Shewanella baltica]
ATGAGTACTTCCAAAAAGCTCACGTTAGAGATGCACCTCGGTGATTTAATGATCGGGGAGTTATCCTTTGATGCGACGAC
CGACACCTTTGCGGTGCATTACACCAAAGACTGGCAACAAAGTGGATTCCCACTATCCCCGACAATTCCCTTAGATGGCA
CAGGAACGAGCAATCAGATATCGATGTTTTTGGTTAACTTATTGCCAGAAAACAAAGGATTAGATTATCTAATTGAATCG
CTTGGCGTCTCCAAGGGAAATACCTTTGCCTTGATCCGTGCAATTGGTCTGGATACCGCTGGTGCTGTTGCTTTTGTTCC
TAAAGGGACTTTGCTGCCTGAAACACAATTGCGGCCAATTAAGACTGAAGAAGTTATTCAGCGCATTGAAGATCCCACAA
TGTGGCCGATGGAAATTTGGGACGGCAAACCACGACTGTCGGTTGCGGGTGTTCAACCTAAATTAAACCTGTTTTATAAC
GGGAAAGAATTCGCATTTGCCGAAGGCGTGCTGTCATCGACCCATATAGTTAAATTCGAAAAGTATCGCCATTTAGTGCT
CAATGAATTTATGACGATGCGCTTAGCTAAGGCGATTGGAATGAATGTGGCGAATGTTGATATCGTTCATTTTGGAGATT
ACAAAGTACTCTGTGTCGAACGCTTTGACCGACGTTATATGCCAAATGAGCAAAGGGTATTAAGAAGGCATATTGTCGAT
AGCTGCCAAGCCCTTGGTTTTAGTGTTAGCAAAAAATATGAACGTAATTTTGGTTCGGGGCGCGATGTTAAAGATATTCG
AGAAGGGGTAAGTTTTAACAGGCTATTTAGTCTTGCCGCAAAATGCCGTAATCCAGTGGCCGCTAAGCAGGATATGTTGC
AGTGGGCGCTGTTCAATTTACTGACCGGCAATGCCGATGCACACGGTAAAAACTACTCATTTTTTATGACGCCAAGCGGA
ATGGAGCCAACCCCTTGGTACGATTTGGTCAGCGTGGCTATGTATGAGGATTTTGAACAACAGCTTGCGATGGCAATTGA
TGACGAATTTGATCCAAATAGCATTTACGCGTATCAATTGGCTGCATTTATTGATGGCTTAGGTTTACCAAGAAATTTAT
TAATCAGTAACTTAACGACAATAGCGCGAAGAATACCGCAGGCAATAGATGGTGTGATTTCAATGCTCCCGCCCCTTGAT
GAAGATGAAGCATCATTTGTGGCTCATTACAAAGCGCAGTTGCTGGCGAGATGTGATCGTTACTTTAGTTTTGCCGCCGA
TGTCAGGGATGTGGAAGTGTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8528.88 Da        Isoelectric Point: 6.2232

>AT103090 WP_107950115.1 NZ_CP028730:725692-725928 [Shewanella baltica]
MASQLNQQSLGLLIKERRKSAALTQDVAAMLCGVTKKTLIRVEKGEDVYISTVFKILDGLGIDIVAAQISDTETNGWY

Download         Length: 237 bp

>AT103090 NZ_CP028730:725692-725928 [Shewanella baltica]
ATGGCATCACAGCTAAATCAACAATCCCTCGGCTTGTTAATTAAAGAACGAAGGAAAAGTGCTGCTCTTACTCAAGACGT
GGCGGCCATGTTGTGCGGCGTAACCAAAAAAACGCTGATCCGAGTTGAAAAAGGTGAGGATGTTTATATCTCAACCGTAT
TCAAAATTCTTGATGGTCTGGGGATTGATATCGTTGCGGCTCAAATCAGCGACACCGAAACTAACGGCTGGTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References