Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 5132362..5133019 Replicon chromosome
Accession NZ_CP028716
Organism Klebsiella pneumoniae strain SCM96

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag DA106_RS25600 Protein ID WP_002916310.1
Coordinates 5132362..5132772 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag DA106_RS25605 Protein ID WP_002916312.1
Coordinates 5132753..5133019 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DA106_RS25580 5128362..5130095 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
DA106_RS25585 5130101..5130814 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DA106_RS25590 5130837..5131733 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
DA106_RS25595 5131834..5132355 + 522 WP_004144730.1 flavodoxin FldB -
DA106_RS25600 5132362..5132772 - 411 WP_002916310.1 protein YgfX Toxin
DA106_RS25605 5132753..5133019 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
DA106_RS25610 5133265..5134248 + 984 WP_020324927.1 tRNA-modifying protein YgfZ -
DA106_RS25615 5134399..5135058 - 660 WP_002916317.1 hemolysin III family protein -
DA106_RS25620 5135222..5135533 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
DA106_RS25625 5135583..5136311 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
DA106_RS25630 5136430..5137863 + 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T103037 WP_002916310.1 NZ_CP028716:c5132772-5132362 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T103037 NZ_CP028716:c5132772-5132362 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAAATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT103037 WP_002916312.1 NZ_CP028716:c5133019-5132753 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT103037 NZ_CP028716:c5133019-5132753 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References