102989

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1335496..1336114 Replicon chromosome
Accession NZ_CP028703
Organism Escherichia coli strain ME8067

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag DBB47_RS06870 Protein ID WP_001291435.1
Coordinates 1335496..1335714 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag DBB47_RS06875 Protein ID WP_000344800.1
Coordinates 1335740..1336114 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBB47_RS06835 1330785..1331357 + 573 WP_000779842.1 YbaY family lipoprotein -
DBB47_RS06840 1331388..1331699 - 312 WP_000409911.1 MGMT family protein -
DBB47_RS06850 1332078..1332431 + 354 WP_000878140.1 DUF1428 domain-containing protein -
DBB47_RS06855 1332473..1334023 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
DBB47_RS06860 1334187..1334657 - 471 WP_000136192.1 YlaC family protein -
DBB47_RS06865 1334773..1335324 - 552 WP_000102564.1 maltose O-acetyltransferase -
DBB47_RS06870 1335496..1335714 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
DBB47_RS06875 1335740..1336114 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
DBB47_RS06880 1336660..1339809 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
DBB47_RS06885 1339832..1341025 - 1194 WP_108118612.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T102989 WP_001291435.1 NZ_CP028703:c1335714-1335496 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T102989 NZ_CP028703:c1335714-1335496 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT102989 WP_000344800.1 NZ_CP028703:c1336114-1335740 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT102989 NZ_CP028703:c1336114-1335740 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References