Detailed information of TA system TA102726

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 3600416..3600894
• Replicon: chromosome
• Accession: NZ_CP028685
• Organism: Escherichia coli strain 111

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A891SFN9
• Locus tag: C9E40_RS19235
• Protein ID: WP_001303876.1
• Coordinates: 3600607..3600894 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: Q8XD67
• Locus tag: C9E40_RS19230
• Protein ID: WP_000536233.1
• Coordinates: 3600416..3600607 (+)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C9E40_RS19195	3595820..3596590	-	771	WP_000450992.1	DUF1627 domain-containing protein	-
C9E40_RS19200	3596612..3597358	-	747	WP_000788751.1	ATP-binding protein	-
C9E40_RS19205	3597365..3598456	-	1092	WP_001205823.1	hypothetical protein	-
C9E40_RS19210	3598535..3598990	+	456	WP_000273724.1	hypothetical protein	-
C9E40_RS19215	3599197..3599622	-	426	WP_000693855.1	Rha family transcriptional regulator	-
C9E40_RS19220	3599606..3599878	-	273	WP_000887453.1	helix-turn-helix domain-containing protein	-
C9E40_RS19225	3599987..3600388	+	402	WP_000986592.1	helix-turn-helix domain-containing protein	-
C9E40_RS19230	3600416..3600607	+	192	WP_000536233.1	hypothetical protein	Antitoxin
C9E40_RS19235	3600607..3600894	+	288	WP_001303876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C9E40_RS19245	3601172..3601327	+	156	WP_000379575.1	DUF1391 family protein	-
C9E40_RS19250	3601469..3601858	+	390	WP_000394511.1	hypothetical protein	-
C9E40_RS19255	3602045..3602230	-	186	WP_001133046.1	hypothetical protein	-
C9E40_RS19265	3602804..3602992	+	189	WP_000413705.1	cell division inhibition protein DicB	-
C9E40_RS19270	3602989..3603180	+	192	WP_001098307.1	DUF1482 family protein	-
C9E40_RS19275	3603274..3605745	+	2472	WP_000034474.1	exonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10978.84 Da
• Isoelectric Point: 10.1360

>T102726 WP_001303876.1 NZ_CP028685:3600607-3600894 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Nucleotide

• Length: 288 bp

>T102726 NZ_CP028685:3600607-3600894 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7025.80 Da
• Isoelectric Point: 4.0270

>AT102726 WP_000536233.1 NZ_CP028685:3600416-3600607 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Nucleotide

• Length: 192 bp

>AT102726 NZ_CP028685:3600416-3600607 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA