Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3600428..3600906 Replicon chromosome
Accession NZ_CP028683
Organism Escherichia coli strain 112

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag C9E41_RS19235 Protein ID WP_001303876.1
Coordinates 3600619..3600906 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag C9E41_RS19230 Protein ID WP_000536233.1
Coordinates 3600428..3600619 (+) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9E41_RS19195 3595832..3596602 - 771 WP_000450992.1 DUF1627 domain-containing protein -
C9E41_RS19200 3596624..3597370 - 747 WP_000788751.1 ATP-binding protein -
C9E41_RS19205 3597377..3598468 - 1092 WP_001205823.1 hypothetical protein -
C9E41_RS19210 3598547..3599002 + 456 WP_000273724.1 hypothetical protein -
C9E41_RS19215 3599209..3599634 - 426 WP_000693855.1 Rha family transcriptional regulator -
C9E41_RS19220 3599618..3599890 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
C9E41_RS19225 3599999..3600400 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
C9E41_RS19230 3600428..3600619 + 192 WP_000536233.1 hypothetical protein Antitoxin
C9E41_RS19235 3600619..3600906 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C9E41_RS19245 3601184..3601339 + 156 WP_000379575.1 DUF1391 family protein -
C9E41_RS19250 3601481..3601870 + 390 WP_000394511.1 hypothetical protein -
C9E41_RS19255 3602057..3602242 - 186 WP_001133046.1 hypothetical protein -
C9E41_RS19265 3602816..3603004 + 189 WP_000413705.1 cell division inhibition protein DicB -
C9E41_RS19270 3603001..3603192 + 192 WP_001098307.1 DUF1482 family protein -
C9E41_RS19275 3603286..3605757 + 2472 WP_000034474.1 exonuclease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T102695 WP_001303876.1 NZ_CP028683:3600619-3600906 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T102695 NZ_CP028683:3600619-3600906 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT102695 WP_000536233.1 NZ_CP028683:3600428-3600619 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT102695 NZ_CP028683:3600428-3600619 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References