Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3471114..3471592 Replicon chromosome
Accession NZ_CP028668
Organism Escherichia coli strain 117

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag C9E46_RS18270 Protein ID WP_001303876.1
Coordinates 3471305..3471592 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag C9E46_RS18265 Protein ID WP_000536233.1
Coordinates 3471114..3471305 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9E46_RS18230 3466518..3467288 - 771 WP_000450992.1 DUF1627 domain-containing protein -
C9E46_RS18235 3467310..3468056 - 747 WP_000788751.1 ATP-binding protein -
C9E46_RS18240 3468063..3469154 - 1092 WP_001205823.1 hypothetical protein -
C9E46_RS18245 3469233..3469688 + 456 WP_000273724.1 hypothetical protein -
C9E46_RS18250 3469895..3470320 - 426 WP_000693855.1 Rha family transcriptional regulator -
C9E46_RS18255 3470304..3470576 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
C9E46_RS18260 3470685..3471086 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
C9E46_RS18265 3471114..3471305 + 192 WP_000536233.1 hypothetical protein Antitoxin
C9E46_RS18270 3471305..3471592 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C9E46_RS18280 3471870..3472025 + 156 WP_000379575.1 DUF1391 family protein -
C9E46_RS18285 3472167..3472556 + 390 WP_000394511.1 hypothetical protein -
C9E46_RS18290 3472743..3472928 - 186 WP_001133046.1 hypothetical protein -
C9E46_RS18300 3473502..3473690 + 189 WP_000413705.1 cell division inhibition protein DicB -
C9E46_RS18305 3473687..3473878 + 192 WP_001098307.1 DUF1482 family protein -
C9E46_RS18310 3473972..3476443 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T102520 WP_001303876.1 NZ_CP028668:3471305-3471592 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T102520 NZ_CP028668:3471305-3471592 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT102520 WP_000536233.1 NZ_CP028668:3471114-3471305 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT102520 NZ_CP028668:3471114-3471305 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References