Detailed information of TA system TA102376

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 3471113..3471591
• Replicon: chromosome
• Accession: NZ_CP028656
• Organism: Escherichia coli strain 121

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A891SFN9
• Locus tag: C9E50_RS18270
• Protein ID: WP_001303876.1
• Coordinates: 3471304..3471591 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: Q8XD67
• Locus tag: C9E50_RS18265
• Protein ID: WP_000536233.1
• Coordinates: 3471113..3471304 (+)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C9E50_RS18230	3466517..3467287	-	771	WP_000450992.1	DUF1627 domain-containing protein	-
C9E50_RS18235	3467309..3468055	-	747	WP_000788751.1	ATP-binding protein	-
C9E50_RS18240	3468062..3469153	-	1092	WP_001205823.1	hypothetical protein	-
C9E50_RS18245	3469232..3469687	+	456	WP_000273724.1	hypothetical protein	-
C9E50_RS18250	3469894..3470319	-	426	WP_000693855.1	Rha family transcriptional regulator	-
C9E50_RS18255	3470303..3470575	-	273	WP_000887453.1	helix-turn-helix domain-containing protein	-
C9E50_RS18260	3470684..3471085	+	402	WP_000986592.1	helix-turn-helix domain-containing protein	-
C9E50_RS18265	3471113..3471304	+	192	WP_000536233.1	hypothetical protein	Antitoxin
C9E50_RS18270	3471304..3471591	+	288	WP_001303876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C9E50_RS18280	3471869..3472024	+	156	WP_000379575.1	DUF1391 family protein	-
C9E50_RS18285	3472166..3472555	+	390	WP_000394511.1	hypothetical protein	-
C9E50_RS18290	3472742..3472927	-	186	WP_001133046.1	hypothetical protein	-
C9E50_RS18300	3473501..3473689	+	189	WP_000413705.1	cell division inhibition protein DicB	-
C9E50_RS18305	3473686..3473877	+	192	WP_001098307.1	DUF1482 family protein	-
C9E50_RS18310	3473971..3476442	+	2472	WP_000034474.1	exonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10978.84 Da
• Isoelectric Point: 10.1360

>T102376 WP_001303876.1 NZ_CP028656:3471304-3471591 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Nucleotide

• Length: 288 bp

>T102376 NZ_CP028656:3471304-3471591 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7025.80 Da
• Isoelectric Point: 4.0270

>AT102376 WP_000536233.1 NZ_CP028656:3471113-3471304 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Nucleotide

• Length: 192 bp

>AT102376 NZ_CP028656:3471113-3471304 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA