Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3550978..3551456 Replicon chromosome
Accession NZ_CP028652
Organism Escherichia coli strain 123

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag C9E52_RS18860 Protein ID WP_001303876.1
Coordinates 3551169..3551456 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag C9E52_RS18855 Protein ID WP_000536233.1
Coordinates 3550978..3551169 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9E52_RS18820 3546382..3547152 - 771 WP_000450992.1 DUF1627 domain-containing protein -
C9E52_RS18825 3547174..3547920 - 747 WP_000788751.1 ATP-binding protein -
C9E52_RS18830 3547927..3549018 - 1092 WP_001205823.1 hypothetical protein -
C9E52_RS18835 3549097..3549552 + 456 WP_000273724.1 hypothetical protein -
C9E52_RS18840 3549759..3550184 - 426 WP_000693855.1 Rha family transcriptional regulator -
C9E52_RS18845 3550168..3550440 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
C9E52_RS18850 3550549..3550950 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
C9E52_RS18855 3550978..3551169 + 192 WP_000536233.1 hypothetical protein Antitoxin
C9E52_RS18860 3551169..3551456 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C9E52_RS18870 3551734..3551889 + 156 WP_000379575.1 DUF1391 family protein -
C9E52_RS18875 3552031..3552420 + 390 WP_000394511.1 hypothetical protein -
C9E52_RS18880 3552607..3552792 - 186 WP_001133046.1 hypothetical protein -
C9E52_RS18890 3553366..3553554 + 189 WP_000413705.1 cell division inhibition protein DicB -
C9E52_RS18895 3553551..3553742 + 192 WP_001098307.1 DUF1482 family protein -
C9E52_RS18900 3553836..3556307 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T102309 WP_001303876.1 NZ_CP028652:3551169-3551456 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T102309 NZ_CP028652:3551169-3551456 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT102309 WP_000536233.1 NZ_CP028652:3550978-3551169 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT102309 NZ_CP028652:3550978-3551169 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References