Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3549412..3549890 Replicon chromosome
Accession NZ_CP028650
Organism Escherichia coli strain 124

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag C9E53_RS18825 Protein ID WP_001303876.1
Coordinates 3549603..3549890 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag C9E53_RS18820 Protein ID WP_000536233.1
Coordinates 3549412..3549603 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9E53_RS18785 3544816..3545586 - 771 WP_000450992.1 DUF1627 domain-containing protein -
C9E53_RS18790 3545608..3546354 - 747 WP_000788751.1 ATP-binding protein -
C9E53_RS18795 3546361..3547452 - 1092 WP_001205823.1 hypothetical protein -
C9E53_RS18800 3547531..3547986 + 456 WP_000273724.1 hypothetical protein -
C9E53_RS18805 3548193..3548618 - 426 WP_000693855.1 Rha family transcriptional regulator -
C9E53_RS18810 3548602..3548874 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
C9E53_RS18815 3548983..3549384 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
C9E53_RS18820 3549412..3549603 + 192 WP_000536233.1 hypothetical protein Antitoxin
C9E53_RS18825 3549603..3549890 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C9E53_RS18835 3550168..3550323 + 156 WP_000379575.1 DUF1391 family protein -
C9E53_RS18840 3550465..3550854 + 390 WP_000394511.1 hypothetical protein -
C9E53_RS18845 3551041..3551226 - 186 WP_001133046.1 hypothetical protein -
C9E53_RS18855 3551800..3551988 + 189 WP_000413705.1 cell division inhibition protein DicB -
C9E53_RS18860 3551985..3552176 + 192 WP_001098307.1 DUF1482 family protein -
C9E53_RS18865 3552270..3554741 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T102278 WP_001303876.1 NZ_CP028650:3549603-3549890 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T102278 NZ_CP028650:3549603-3549890 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT102278 WP_000536233.1 NZ_CP028650:3549412-3549603 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT102278 NZ_CP028650:3549412-3549603 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References