Detailed information of TA system    

experimentalExperimentally validated    

Overview


TA module


Type VIII Classification (family/domain) creTA/-
Location 2730357..2730639 Replicon chromosome
Accession NZ_CP028561
Organism Acinetobacter sp. WCHA45

Toxin (RNA)


Gene name creT
Locus tag -
Coordinates 2730357..2730400 (-)

Antitoxin (RNA)


Gene name creA
Locus tag -
Coordinates 2730592..2730639 (+)

Genomic Context


--CDG55_RS14480CDG55_RS14485CDG55_RS14490CDG55_RS14495--CDG55_RS14500CDG55_RS14505
Location: 2730592..2730639 (48 bp)
Type: Antitoxin
Protein ID: -
Location: 2726160..2726774 (615 bp)
Type: Others
Protein ID: WP_087536696.1
Location: 2726774..2727814 (1041 bp)
Type: Others
Protein ID: WP_087536695.1
Location: 2727817..2728923 (1107 bp)
Type: Others
Protein ID: WP_087536694.1
Location: 2728923..2730257 (1335 bp)
Type: Others
Protein ID: WP_087536693.1
Location: 2730357..2730400 (44 bp)
Type: Toxin
Protein ID: -
Location: 2730664..2734149 (3486 bp)
Type: Others
Protein ID: WP_087536692.1
Location: 2734146..2735114 (969 bp)
Type: Others
Protein ID: WP_087536691.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CDG55_RS14480 (CDG55_14470)2726160..2726774-615WP_087536696.1type I-F CRISPR-associated endoribonuclease Cas6/Csy4-
CDG55_RS14485 (CDG55_14475)2726774..2727814-1041WP_087536695.1type I-F CRISPR-associated protein Csy3-
CDG55_RS14490 (CDG55_14480)2727817..2728923-1107WP_087536694.1type I-F CRISPR-associated protein Csy2-
CDG55_RS14495 (CDG55_14485)2728923..2730257-1335WP_087536693.1type I-F CRISPR-associated protein Csy1-
-2730357..2730400-44--Toxin
-2730592..2730639+48--Antitoxin
CDG55_RS14500 (CDG55_14490)2730664..2734149-3486WP_087536692.1type I-F CRISPR-associated helicase Cas3-
CDG55_RS14505 (CDG55_14495)2734146..2735114-969WP_087536691.1type I-F CRISPR-associated endonuclease Cas1f-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Sequences


Toxin        


Download         Length: 44 bp

>T10220 NZ_CP028561:c2730400-2730357 [Acinetobacter sp. WCHA45]
GTAAGGGGGAAATAATGTTTAGCACGCATTTAATCAGAAGGGTC

Antitoxin


Download         Length: 48 bp

>AT10220 NZ_CP028561:2730592-2730639 [Acinetobacter sp. WCHA45]
CTTAGAAATAGTTCCTTTTATTCAATCTGTTCACTGCCATATAGGCAG

Structures


Antitoxin

Download structure file

Antitoxin

Download structure file

References


(1) Rui Wang et al. (2023) Associate toxin-antitoxin with CRISPR-Cas to kill multidrug-resistant pathogens. Nature Communications 14(1):2078. [PubMed:37045931] experimental


experimental experimental literature