Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) PhoH-LOG/-
Location 1850771..1853080 Replicon chromosome
Accession NC_005070
Organism Synechococcus sp. WH 8102

Toxin (Protein)


Gene name PhoH Uniprot ID Q7U4W7
Locus tag TX72_RS09785 Protein ID WP_011128804.1
Coordinates 1850771..1852159 (+) Length 463 a.a.

Antitoxin (Protein)


Gene name LOG Uniprot ID -
Locus tag TX72_RS09790 Protein ID WP_042503808.1
Coordinates 1852199..1853080 (+) Length 294 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TX72_RS09775 1847963..1848163 - 201 WP_042503806.1 hypothetical protein -
TX72_RS13305 (SYNW1944) 1848904..1849150 - 247 Protein_2025 DUF1651 domain-containing protein -
TX72_RS09780 1849244..1849426 - 183 WP_042504430.1 hypothetical protein -
TX72_RS09785 (SYNW1946) 1850771..1852159 + 1389 WP_011128804.1 PhoH family protein Toxin
TX72_RS09790 (SYNW1947) 1852199..1853080 + 882 WP_042503808.1 LOG family protein Antitoxin
TX72_RS13645 1854334..1854777 + 444 WP_083810666.1 hypothetical protein -
TX72_RS09805 (SYNW1950) 1855018..1855200 + 183 WP_011128808.1 DUF4278 domain-containing protein -
TX72_RS09810 (SYNW1952) 1855822..1857228 - 1407 WP_011128810.1 glycoside hydrolase family 13 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1844466..1855200 10734


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PhoH-like protein

(239-453)

Antitoxin

LOG family

(153-283)


Sequences

Toxin        


Download         Length: 463 a.a.        Molecular weight: 50806.74 Da        Isoelectric Point: 5.4823

>T10192 WP_011128804.1 NC_005070:1850771-1852159 [Synechococcus sp. WH 8102]
MKDKIVVLDTNVLLHDPEAPHRFGDLRVVIPMQVVEEIDRFKKDHSEKGRNARRISRLLDSYRDRGCLADGVPIEGTNHG
LLQVIFCQAHALDALPAELQGGGGDNNILAVALEQLRRGGLKQAPEVVLISKDINLRIKADAVGLQAEDYVNDNVSIDDL
YAGFRELSTDAVTISSLHDEGQLPLDAVTDPEGQHPQANEGVVLVDERNDSRTLLARRQGNSNSLKPLDWLNRAHLGRIK
ARNREQSFALDLLLDPSVALVTLVGKAGTGKTLLAIAAGLHQVADTHHYARLLVTRPPISLGKDIGYLPGTLEEKLGPWM
KPIIDNIDFITGSSPGEDSEQKKKQRHREPRNAWADLQGMGLLEVEAINTIRGRSIPQQFLVVDEAQNLTPLEVKTIVTR
VGEGTKVVFTGDPYQIDNPYVDAESNGLTWLVEKLKDQPLVGHMTLTKGERSELAELAANIL

Download         Length: 1389 bp

>T10192 NC_005070:1850771-1852159 [Synechococcus sp. WH 8102]
ATGAAAGACAAAATCGTCGTTCTCGACACGAATGTTCTGCTTCACGATCCTGAGGCTCCACACCGCTTTGGAGATCTGAG
GGTTGTGATCCCAATGCAAGTGGTTGAGGAAATTGATCGCTTTAAAAAAGATCACTCTGAAAAAGGCCGAAACGCCCGGC
GAATTTCAAGACTCCTGGATTCCTATCGAGACCGCGGATGCCTTGCCGATGGTGTTCCCATTGAGGGCACGAATCACGGC
CTGCTTCAGGTAATTTTCTGTCAGGCCCATGCTCTTGACGCCTTACCGGCAGAGCTTCAGGGGGGCGGCGGCGACAACAA
CATCCTCGCAGTGGCCCTTGAGCAGCTGCGGCGCGGTGGGCTGAAACAGGCCCCGGAGGTTGTGCTGATCAGCAAAGACA
TCAACCTGAGAATCAAGGCCGACGCGGTAGGCCTGCAAGCCGAGGACTACGTCAATGACAACGTCTCGATTGATGACCTC
TATGCAGGGTTCCGGGAACTCAGCACTGATGCAGTGACGATCTCGAGTCTGCATGACGAGGGTCAGCTCCCTCTGGACGC
TGTCACCGATCCAGAGGGGCAGCACCCACAGGCAAATGAAGGCGTGGTGCTGGTGGATGAGCGCAACGACAGCCGCACCT
TGCTTGCCCGGCGTCAAGGAAACAGCAACTCACTTAAACCACTTGACTGGCTGAATCGTGCCCATTTGGGACGGATCAAG
GCGAGAAATCGGGAGCAAAGTTTTGCGCTGGATTTGCTGCTCGATCCATCCGTTGCTCTGGTGACCCTAGTGGGCAAGGC
AGGCACAGGCAAAACGCTGCTGGCCATTGCCGCTGGTTTGCACCAGGTGGCCGACACCCATCACTACGCCCGTCTGCTGG
TGACACGTCCGCCAATCTCCCTCGGCAAAGACATTGGCTACCTGCCTGGAACGCTTGAAGAGAAACTTGGGCCTTGGATG
AAGCCGATCATCGACAACATCGACTTCATCACCGGCTCTTCTCCCGGCGAGGACTCTGAGCAGAAGAAGAAGCAGCGGCA
CCGCGAACCACGCAACGCCTGGGCTGATCTGCAAGGCATGGGTTTGTTGGAGGTTGAAGCGATAAACACCATCCGCGGGC
GCTCAATTCCCCAACAGTTTCTGGTGGTGGATGAAGCGCAAAACCTGACGCCCTTGGAAGTGAAGACGATCGTCACGCGG
GTGGGTGAAGGAACCAAGGTTGTCTTTACCGGTGATCCGTATCAAATCGACAACCCATACGTGGATGCCGAAAGCAACGG
GCTCACATGGCTGGTGGAAAAGCTCAAAGATCAGCCTCTGGTAGGACACATGACCCTCACCAAAGGAGAGCGCAGTGAAC
TGGCTGAACTAGCCGCCAACATCCTCTGA

Antitoxin


Download         Length: 294 a.a.        Molecular weight: 32630.96 Da        Isoelectric Point: 5.8126

>AT10192 WP_042503808.1 NC_005070:1852199-1853080 [Synechococcus sp. WH 8102]
MTQFPETSTPEQANLDAILNSPTYRIAHEDPELMNSNVMRGVRMLLEITKPDLHLETAGIESTIIVFGGARIVDRDTAHQ
RLKDAEKNFNQDPNSSTLKRKVINAQHLIELSRFYDAARQFAYLASQHGQASKGQGHGCASHVIVTGGGPGIMEAANRGA
FDAGCRSIGLNITLPFEQHPNPYITPDLCFKFNYFSLRKFHFVMRSVGAILFPGGFGTLDELFELLTLRQVGTKGRMPIV
LFGTEFWTKLVDFDYLAESGLISNDDLALIRFSDTAEEAWEYIQSSTEPVRGQ

Download         Length: 882 bp

>AT10192 NC_005070:1852199-1853080 [Synechococcus sp. WH 8102]
ATGACTCAATTTCCAGAAACCTCAACACCTGAGCAAGCCAATCTGGATGCCATTCTGAATTCACCTACTTACAGAATTGC
CCATGAAGATCCCGAGTTGATGAACAGCAATGTCATGCGTGGTGTGCGCATGCTGCTTGAAATCACCAAGCCGGATCTGC
ATCTGGAGACAGCCGGGATAGAATCGACGATCATTGTCTTTGGTGGTGCCAGGATCGTCGACAGAGACACCGCTCATCAG
CGGCTAAAAGATGCAGAGAAAAATTTTAACCAAGATCCAAATTCATCAACTCTAAAGAGGAAAGTGATTAATGCTCAGCA
CTTAATTGAACTTTCTCGTTTTTATGACGCCGCTCGACAATTTGCCTACTTGGCGTCCCAGCATGGTCAGGCCAGCAAGG
GGCAAGGCCATGGCTGCGCATCTCATGTAATCGTGACTGGTGGTGGTCCCGGAATCATGGAAGCTGCCAACCGTGGCGCA
TTTGATGCAGGATGCCGATCAATCGGACTCAACATCACACTTCCCTTTGAACAACACCCCAATCCCTACATCACACCAGA
TCTTTGCTTCAAATTCAATTATTTCTCACTCCGCAAATTTCACTTTGTGATGCGCTCTGTGGGAGCTATTTTATTTCCAG
GAGGTTTTGGCACGCTTGATGAACTGTTTGAGTTGCTGACCTTGCGGCAAGTTGGAACTAAAGGACGCATGCCAATTGTG
TTATTTGGAACAGAGTTCTGGACGAAGCTTGTGGACTTCGACTACCTCGCCGAATCAGGCTTAATTTCAAATGATGACCT
AGCTCTAATTCGTTTTTCGGATACTGCCGAGGAAGCCTGGGAATATATACAAAGCAGCACTGAGCCAGTCCGCGGGCAAT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7U4W7

Antitoxin

Source ID Structure

References

(1) Ayalla Fedida et al. (2017) Two Synechococcus genes, Two Different Effects on Cyanophage Infection. Viruses 9(6):136. [PubMed:28574452] experimental


experimental experimental literature