101862

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 401715..402515 Replicon chromosome
Accession NZ_CP028617
Organism Escherichia coli strain 140

Toxin (Protein)


Gene name ataT Uniprot ID A0A891SNC1
Locus tag C9E64_RS01955 Protein ID WP_000342448.1
Coordinates 401988..402515 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag C9E64_RS01950 Protein ID WP_001277108.1
Coordinates 401715..401981 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9E64_RS01930 397373..398041 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
C9E64_RS01935 398034..399092 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
C9E64_RS01940 399337..400191 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
C9E64_RS01945 400462..401565 + 1104 WP_001021996.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
C9E64_RS01950 401715..401981 + 267 WP_001277108.1 DUF1778 domain-containing protein Antitoxin
C9E64_RS01955 401988..402515 + 528 WP_000342448.1 GNAT family N-acetyltransferase Toxin
C9E64_RS01960 402512..402895 - 384 WP_000778769.1 aspartate 1-decarboxylase autocleavage activator PanM -
C9E64_RS01965 403319..404428 + 1110 WP_001301528.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
C9E64_RS01970 404476..405402 + 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
C9E64_RS01975 405399..406676 + 1278 WP_000803797.1 branched chain amino acid ABC transporter permease LivM -
C9E64_RS01980 406673..407440 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(88-150)

Antitoxin

(8-86)


Sequences


Toxin        


Download         Length: 176 a.a.        Molecular weight: 19692.68 Da        Isoelectric Point: 7.3232

>T101862 WP_000342448.1 NZ_CP028617:401988-402515 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYKSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

>T101862 NZ_CP028617:401988-402515 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATAAATCGCTGGGCTTTATCCCTTTAGTCGGGGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT101862 WP_001277108.1 NZ_CP028617:401715-401981 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp

>AT101862 NZ_CP028617:401715-401981 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6GTS


Antitoxin

Source ID Structure
AlphaFold DB A0A829CN24

References