Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | fic-relB/- |
| Location | 1301881..1303637 | Replicon | chromosome |
| Accession | NZ_HG004426 | ||
| Organism | Campylobacter fetus subsp. venerealis str. 84-112 | ||
Toxin (Protein)
| Gene name | Fic | Uniprot ID | C5H2Y4 |
| Locus tag | CSG_RS06655 | Protein ID | WP_002850956.1 |
| Coordinates | 1301881..1302801 (-) | Length | 307 a.a. |
Antitoxin (Protein)
| Gene name | Fic | Uniprot ID | B2CG46 |
| Locus tag | CSG_RS06660 | Protein ID | WP_002850958.1 |
| Coordinates | 1302801..1303637 (-) | Length | 279 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CSG_RS06625 (CSG_13360) | 1297057..1297407 | - | 351 | WP_035170727.1 | hypothetical protein | - |
| CSG_RS06630 (CSG_13370) | 1297524..1298489 | - | 966 | WP_035170725.1 | hypothetical protein | - |
| CSG_RS06635 (CSG_13380) | 1298486..1299241 | - | 756 | WP_035170722.1 | hypothetical protein | - |
| CSG_RS06640 (CSG_13390) | 1299321..1299761 | - | 441 | WP_035170721.1 | hypothetical protein | - |
| CSG_RS06645 (CSG_13400) | 1300266..1301603 | + | 1338 | WP_035148452.1 | hypothetical protein | - |
| CSG_RS06650 (CSG_13410) | 1301612..1301881 | - | 270 | WP_035148454.1 | hypothetical protein | - |
| CSG_RS06655 (CSG_13420) | 1301881..1302801 | - | 921 | WP_002850956.1 | Fic family protein | Toxin |
| CSG_RS06660 (CSG_13430) | 1302801..1303637 | - | 837 | WP_002850958.1 | Fic family protein | Antitoxin |
| CSG_RS06665 (CSG_13440) | 1303641..1303943 | - | 303 | WP_080582791.1 | DUF86 domain-containing protein | - |
| CSG_RS06670 (CSG_13450) | 1304065..1304376 | - | 312 | WP_002850963.1 | nucleotidyltransferase domain-containing protein | - |
| CSG_RS06675 (CSG_13460) | 1304444..1305106 | - | 663 | WP_002850964.1 | AAA family ATPase | - |
| CSG_RS06680 (CSG_13470) | 1305131..1305448 | - | 318 | WP_010400644.1 | hypothetical protein | - |
| CSG_RS06685 (CSG_13480) | 1305516..1306226 | - | 711 | WP_002850968.1 | hypothetical protein | - |
| CSG_RS10260 (CSG_13490) | 1306429..1306644 | - | 216 | WP_002850970.1 | hypothetical protein | - |
| CSG_RS10265 (CSG_13500) | 1306641..1306895 | - | 255 | WP_010400630.1 | hypothetical protein | - |
| CSG_RS10520 (CSG_13510) | 1306892..1308112 | - | 1221 | WP_002850972.1 | hypothetical protein | - |
| CSG_RS06705 (CSG_13520) | 1308109..1308606 | - | 498 | WP_002850973.1 | lytic transglycosylase domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1267670..1330033 | 62363 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 307 a.a. Molecular weight: 35445.26 Da Isoelectric Point: 9.2339
>T10185 WP_002850956.1 NZ_HG004426:c1302801-1301881 [Campylobacter fetus subsp. venerealis str. 84-112]
MQEQYTEIKDSNIINKQNIDIAVGLGLVDDLKPSEYFYKAVEKSRTYNELEDNVKKYYDGKKLDKKEVGEKECDIVSVNI
AKYLEKSGFTLSPVTLKTIHKNLFWDAFPQGLEKYVGVFRDVNISKKEEVLGGEKSVEYGNYDELGDMLDYDFDREKRKD
YAKMTRQEQALNVGKFVSGVWQIHPFREGNTRTIAVFTIKYLQSKGFEANNDIFKENSKYFRDALVLANYDNMKENIKSD
FSYLESFFNKFILNKNIELKLLPNSPKGHKSEKSVLSRLGAAYDKKVQSGAIKQPQISKKSKEKER
MQEQYTEIKDSNIINKQNIDIAVGLGLVDDLKPSEYFYKAVEKSRTYNELEDNVKKYYDGKKLDKKEVGEKECDIVSVNI
AKYLEKSGFTLSPVTLKTIHKNLFWDAFPQGLEKYVGVFRDVNISKKEEVLGGEKSVEYGNYDELGDMLDYDFDREKRKD
YAKMTRQEQALNVGKFVSGVWQIHPFREGNTRTIAVFTIKYLQSKGFEANNDIFKENSKYFRDALVLANYDNMKENIKSD
FSYLESFFNKFILNKNIELKLLPNSPKGHKSEKSVLSRLGAAYDKKVQSGAIKQPQISKKSKEKER
Download Length: 921 bp
>T10185 NZ_HG004426:c1302801-1301881 [Campylobacter fetus subsp. venerealis str. 84-112]
ATGCAAGAACAATATACGGAAATCAAAGATAGCAATATTATTAATAAACAAAACATAGATATTGCAGTAGGGCTTGGGCT
TGTAGATGATCTGAAGCCTTCTGAGTATTTTTATAAGGCTGTTGAAAAATCGCGAACATACAACGAACTTGAAGACAATG
TAAAGAAATATTATGATGGCAAAAAGCTAGATAAAAAAGAGGTCGGCGAAAAAGAGTGCGATATAGTTTCAGTAAATATC
GCCAAGTATTTAGAAAAAAGTGGCTTTACGCTATCTCCTGTTACATTGAAGACTATACATAAAAATTTATTTTGGGATGC
CTTTCCACAAGGGCTTGAAAAATATGTTGGAGTTTTTAGGGATGTAAATATTTCAAAAAAAGAAGAAGTCTTGGGTGGCG
AAAAAAGCGTAGAGTATGGTAATTATGATGAGCTTGGCGATATGCTGGATTATGATTTTGATAGAGAAAAACGCAAAGAT
TACGCCAAAATGACTAGGCAAGAACAGGCTTTAAATGTCGGCAAATTTGTAAGCGGGGTATGGCAAATTCATCCGTTTCG
AGAAGGCAATACTAGGACAATTGCGGTTTTTACTATTAAGTATCTGCAAAGTAAAGGCTTTGAAGCAAACAACGATATCT
TTAAAGAAAACTCAAAATATTTCAGGGATGCTTTAGTGTTAGCAAATTACGACAATATGAAAGAAAATATAAAAAGTGAT
TTTTCATACCTAGAGAGTTTTTTTAACAAATTTATTCTAAATAAAAATATAGAGTTAAAACTGCTACCAAACAGCCCAAA
AGGTCACAAAAGTGAGAAATCAGTCCTATCTAGACTTGGTGCAGCCTATGACAAAAAGGTGCAAAGTGGAGCGATCAAAC
AACCACAAATAAGCAAAAAATCAAAAGAAAAGGAAAGATAA
ATGCAAGAACAATATACGGAAATCAAAGATAGCAATATTATTAATAAACAAAACATAGATATTGCAGTAGGGCTTGGGCT
TGTAGATGATCTGAAGCCTTCTGAGTATTTTTATAAGGCTGTTGAAAAATCGCGAACATACAACGAACTTGAAGACAATG
TAAAGAAATATTATGATGGCAAAAAGCTAGATAAAAAAGAGGTCGGCGAAAAAGAGTGCGATATAGTTTCAGTAAATATC
GCCAAGTATTTAGAAAAAAGTGGCTTTACGCTATCTCCTGTTACATTGAAGACTATACATAAAAATTTATTTTGGGATGC
CTTTCCACAAGGGCTTGAAAAATATGTTGGAGTTTTTAGGGATGTAAATATTTCAAAAAAAGAAGAAGTCTTGGGTGGCG
AAAAAAGCGTAGAGTATGGTAATTATGATGAGCTTGGCGATATGCTGGATTATGATTTTGATAGAGAAAAACGCAAAGAT
TACGCCAAAATGACTAGGCAAGAACAGGCTTTAAATGTCGGCAAATTTGTAAGCGGGGTATGGCAAATTCATCCGTTTCG
AGAAGGCAATACTAGGACAATTGCGGTTTTTACTATTAAGTATCTGCAAAGTAAAGGCTTTGAAGCAAACAACGATATCT
TTAAAGAAAACTCAAAATATTTCAGGGATGCTTTAGTGTTAGCAAATTACGACAATATGAAAGAAAATATAAAAAGTGAT
TTTTCATACCTAGAGAGTTTTTTTAACAAATTTATTCTAAATAAAAATATAGAGTTAAAACTGCTACCAAACAGCCCAAA
AGGTCACAAAAGTGAGAAATCAGTCCTATCTAGACTTGGTGCAGCCTATGACAAAAAGGTGCAAAGTGGAGCGATCAAAC
AACCACAAATAAGCAAAAAATCAAAAGAAAAGGAAAGATAA
Antitoxin
Download Length: 279 a.a. Molecular weight: 31851.33 Da Isoelectric Point: 8.5962
>AT10185 WP_002850958.1 NZ_HG004426:c1303637-1302801 [Campylobacter fetus subsp. venerealis str. 84-112]
MDGGVNLGNFLKNNNERDYWLDVCVRMAHHSTAIEGNTLSQDETASILLDGYIAKATSEREFYEVKNYRQILPKMFSSLQ
EKAKIDEKLIKDFHRLIMNNLIDNNGKFKTIENLVVGANFEPTKPYLVPVAIKDMCDNLYFRLDNAKNDDDKLKAILQSH
IKFEKIHPFSDGNGRTGRIIMIYGCLENNLAPIIIPKEQKNRYIAILRNNDIDGFMAFAKEIEKDEISRRNKFLSQRPNE
QDNSKSVLSRLGNAYAKKLESGAIKALNDTANSKEKER
MDGGVNLGNFLKNNNERDYWLDVCVRMAHHSTAIEGNTLSQDETASILLDGYIAKATSEREFYEVKNYRQILPKMFSSLQ
EKAKIDEKLIKDFHRLIMNNLIDNNGKFKTIENLVVGANFEPTKPYLVPVAIKDMCDNLYFRLDNAKNDDDKLKAILQSH
IKFEKIHPFSDGNGRTGRIIMIYGCLENNLAPIIIPKEQKNRYIAILRNNDIDGFMAFAKEIEKDEISRRNKFLSQRPNE
QDNSKSVLSRLGNAYAKKLESGAIKALNDTANSKEKER
Download Length: 837 bp
>AT10185 NZ_HG004426:c1303637-1302801 [Campylobacter fetus subsp. venerealis str. 84-112]
ATGGATGGCGGTGTAAATTTAGGCAATTTCTTAAAAAACAACAACGAGCGAGACTATTGGCTAGATGTATGTGTTCGTAT
GGCTCATCATAGCACAGCAATCGAGGGCAATACTTTAAGTCAGGATGAGACTGCTTCAATCTTGCTTGATGGCTATATAG
CAAAAGCAACTAGCGAGCGTGAATTTTATGAAGTAAAAAACTATCGCCAAATTTTGCCAAAAATGTTTTCATCTTTACAA
GAAAAAGCCAAGATAGACGAGAAGCTAATAAAAGATTTTCATAGGCTAATAATGAATAATTTAATAGACAACAACGGCAA
ATTTAAAACTATCGAAAATTTAGTTGTAGGCGCAAATTTCGAACCTACAAAGCCGTATCTAGTGCCAGTAGCAATTAAAG
ATATGTGCGATAATCTATATTTTAGACTTGATAATGCCAAAAATGACGACGATAAGCTAAAAGCAATATTGCAAAGCCAT
ATCAAATTTGAAAAAATTCATCCTTTTAGTGACGGAAACGGCAGAACCGGCAGGATAATTATGATCTATGGTTGTTTAGA
GAATAATTTAGCACCAATTATAATACCAAAAGAGCAAAAAAATAGATACATTGCAATACTGCGCAACAATGACATCGATG
GATTTATGGCGTTTGCTAAAGAAATAGAAAAAGATGAAATATCAAGGCGTAATAAATTTTTAAGCCAACGACCAAATGAG
CAAGATAATAGTAAATCAGTCTTATCTAGGCTCGGCAATGCTTACGCCAAAAAGCTAGAAAGCGGAGCGATCAAAGCATT
AAATGATACCGCAAATTCAAAGGAAAAGGAGAGATAA
ATGGATGGCGGTGTAAATTTAGGCAATTTCTTAAAAAACAACAACGAGCGAGACTATTGGCTAGATGTATGTGTTCGTAT
GGCTCATCATAGCACAGCAATCGAGGGCAATACTTTAAGTCAGGATGAGACTGCTTCAATCTTGCTTGATGGCTATATAG
CAAAAGCAACTAGCGAGCGTGAATTTTATGAAGTAAAAAACTATCGCCAAATTTTGCCAAAAATGTTTTCATCTTTACAA
GAAAAAGCCAAGATAGACGAGAAGCTAATAAAAGATTTTCATAGGCTAATAATGAATAATTTAATAGACAACAACGGCAA
ATTTAAAACTATCGAAAATTTAGTTGTAGGCGCAAATTTCGAACCTACAAAGCCGTATCTAGTGCCAGTAGCAATTAAAG
ATATGTGCGATAATCTATATTTTAGACTTGATAATGCCAAAAATGACGACGATAAGCTAAAAGCAATATTGCAAAGCCAT
ATCAAATTTGAAAAAATTCATCCTTTTAGTGACGGAAACGGCAGAACCGGCAGGATAATTATGATCTATGGTTGTTTAGA
GAATAATTTAGCACCAATTATAATACCAAAAGAGCAAAAAAATAGATACATTGCAATACTGCGCAACAATGACATCGATG
GATTTATGGCGTTTGCTAAAGAAATAGAAAAAGATGAAATATCAAGGCGTAATAAATTTTTAAGCCAACGACCAAATGAG
CAAGATAATAGTAAATCAGTCTTATCTAGGCTCGGCAATGCTTACGCCAAAAAGCTAGAAAGCGGAGCGATCAAAGCATT
AAATGATACCGCAAATTCAAAGGAAAAGGAGAGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7D7L3Y5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7D7Q668 |
References
(1) Hanna Sprenger et al. (2017) Fic Proteins of Campylobacter fetus subsp. venerealis Form a Network of Functional Toxin-Antitoxin Systems. Frontiers in Microbiology 8:1965. [PubMed:29089929]