10178

Detailed information of TA system    

experimentalExperimentally validated    

Overview


TA module


Type II Classification (family/domain) sam/-
Location 1226550..1230884 Replicon chromosome
Accession NZ_LT571449
Organism Staphylococcus epidermidis isolate BPH0662

Toxin (Protein)


Gene name sam-T Uniprot ID Q5HPA1
Locus tag BN6763_RS06135 Protein ID WP_001830929.1
Coordinates 1226550..1227428 (-) Length 293 a.a.

Antitoxin (Protein)


Gene name sam-AT Uniprot ID A0A8X8FQH6
Locus tag BN6763_RS06140 Protein ID WP_002504864.1
Coordinates 1227447..1230884 (-) Length 1146 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN6763_RS06135 1226550..1227428 - 879 WP_001830929.1 5'-3' exonuclease Toxin
BN6763_RS06140 1227447..1230884 - 3438 WP_002504864.1 dynamin family protein Antitoxin
BN6763_RS06145 1231261..1231899 - 639 WP_001831317.1 SDR family oxidoreductase -
BN6763_RS06150 1232067..1233203 - 1137 WP_001831166.1 class I SAM-dependent RNA methyltransferase -
BN6763_RS06160 1233846..1234184 - 339 WP_001831034.1 cell division regulator GpsB -
BN6763_RS06165 1234198..1234764 - 567 WP_001831285.1 DUF1273 domain-containing protein -
BN6763_RS06170 1234776..1235108 - 333 WP_001831244.1 YppE family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(176-248)

Antitoxin

(592-803)


Sequences


Toxin        


Download         Length: 293 a.a.        Molecular weight: 33511.09 Da        Isoelectric Point: 6.3098

>T10178 WP_001830929.1 NZ_LT571449:c1227428-1226550 [Staphylococcus epidermidis]
MPQRVLLVDGMALLFRHFYATSLHNQFMYNSKGIPTNGIQGFVRHIFSAIKEIEPTHVAVCWDMGQETFRNEMYDGYKQN
RPAPPDELIPQFDYVKEISHQFGFVNVGKRNYEADDIIGSLAETYSQEHEVYIITGDRDLLQCINHNVEVWLIKKGFTIY
QRYTLDRFIDEYGLNPQQLIDVKAFMGDTADGYSGVKGIGEKTAIKLIQNHGTVENVVNNLSSLTPAQQKKITNNLNHLH
LSKSLAEIYTKVPIETDKLFKEMTYAHTLNEILSICNEHELYVSSKYIATHL

Download         Length: 879 bp

>T10178 NZ_LT571449:c1227428-1226550 [Staphylococcus epidermidis]
ATGCCTCAAAGAGTATTGCTCGTTGATGGAATGGCTTTATTATTTAGACATTTTTATGCAACAAGCTTACACAATCAATT
TATGTACAATTCTAAAGGAATTCCTACAAATGGTATTCAAGGTTTTGTAAGACATATTTTTAGCGCTATCAAGGAAATCG
AACCTACTCACGTAGCAGTTTGTTGGGATATGGGGCAAGAAACATTCAGAAATGAAATGTATGATGGCTATAAACAAAAT
CGCCCAGCACCTCCTGATGAACTTATTCCTCAATTCGATTATGTTAAAGAAATATCCCATCAGTTTGGTTTTGTAAATGT
TGGTAAGCGTAATTATGAAGCTGATGATATTATTGGCAGTTTAGCGGAAACATATTCACAAGAACATGAAGTTTATATCA
TTACCGGAGACCGAGACTTACTCCAATGCATTAATCATAATGTAGAAGTTTGGCTTATAAAAAAAGGTTTTACAATCTAT
CAACGTTACACGCTTGATCGTTTCATTGATGAATACGGGCTTAATCCTCAACAATTAATAGATGTTAAAGCTTTTATGGG
TGATACAGCAGATGGCTATTCTGGTGTAAAAGGGATAGGTGAAAAAACAGCAATTAAATTAATTCAAAATCATGGAACTG
TCGAAAATGTAGTGAACAATTTATCATCATTAACTCCCGCTCAACAGAAAAAAATAACAAATAATTTAAATCATCTGCAT
TTATCAAAATCACTCGCAGAAATATATACCAAAGTTCCAATTGAAACAGACAAACTTTTTAAAGAGATGACATATGCTCA
TACACTAAATGAGATTTTATCCATTTGTAATGAACATGAACTATACGTTTCAAGTAAATATATTGCAACTCACCTCTAA

Antitoxin


Download         Length: 1146 a.a.        Molecular weight: 134088.94 Da        Isoelectric Point: 5.0625

>AT10178 WP_002504864.1 NZ_LT571449:c1230884-1227447 [Staphylococcus epidermidis]
MAINEQLDTLYKLKKELEKSNNRPLINTINQVIKKVYLNQYTATFVGHFSAGKSTLINLLLEQDILPSSPVPTTSNTAIV
SVAKEDEIIANLTQQQYTKLKTYNDVKQMNRQNVDVESIEINFPSNKFNLGFTFQDTPGVDSNVATHQSSTEQFMYTSNL
LFYTVDYNHVQSALNFKFMKRINEVGIPIIFVINQIDKHNEEEITFETFKSRVEKSIKDWDIKLQDTYYVSKFDHPQNEI
DKLSNFLVFMDQHRESTEDYVNRTIQFITDAQYIYIQNEMQSILDTLQINEEQFEEAYIQFQQNQEVSAEAQLLNDSNQL
FNYLKQKRKDILDNAYIMTYDMRESLRNYLESMATDFKVNGYFNKRKKKEEEQIKRLNEATTQLQEKVNQQVRQPLREDM
SFLTRFINKHAVNEKILNQEYDVVPSLISELYQTQTSISNTYVLTFSDEVIKALNKKIENESTPLFEEAVNHVQVNELSS
DENEDRYEYDRYIELNTLKDSLTSHNYKHYYIHLDDSLDKLIGRTETHFELKQENSTAYHRKHETQHRNEFVTSNQDIKR
ALDIVKDVPLFDRTKQDITDTILRLDNQITKVGVFGTFSAGKSSLINALLGDNYLVSSPNPTTAATTELSYGKESQITLK
SKEQLLEEVNHVLEFYEISFNTLDNFIKSDLEKLKSKLEKNQLAFISAIEKHYEMYTSMLEHSLIHTVSLEEIKKWSAED
EYATFVKTVHLKLPLDWLKGKIIIDSLGLHSNNQRHTNETEQILTSSDLILYVTYFNHSFTDNDKAFIEHMKDMNQLNEN
QAFKMIINAVDLAEDKQDIQAVEDYVADALGQVNLHSDIYSVSSRQSLNGNNIGINELRESIQYFAKVESRTILEQQMTY
QLQQMNNSFKKMIKDFHDDNAKLSARQHKLNHYKNQTLLNQELIDTTAQRTFNEVEEQVYHLNERLKLQLLDEVKSVFNS
QMTQNNDFNEEKKISTKIYLDQIHQRLFLEQSLITERIKKYFNSQLEEQILPVMKKLNQIHVIINAKFNVEPSLVDTALL
QIELNSMLQSLPKQLTKRKIVNPKSQKDIQVHIANQTLELLQDDLNSLRRQLNDYIHEMTQLAEHQFQMLETSIQQQIDE
LLSFTIDDTLIQQLELKTTQLDNIL

Download         Length: 3438 bp

>AT10178 NZ_LT571449:c1230884-1227447 [Staphylococcus epidermidis]
ATGGCAATAAATGAACAATTAGATACTTTATATAAATTAAAAAAAGAATTGGAAAAATCTAATAACAGACCTTTAATTAA
TACCATTAATCAAGTAATAAAAAAAGTTTATTTAAATCAATACACCGCAACATTTGTAGGACATTTCTCAGCTGGAAAAT
CAACGTTAATTAATTTGTTATTAGAACAAGATATACTACCAAGTTCTCCAGTACCAACAACGAGCAATACAGCTATCGTT
TCAGTAGCCAAGGAAGACGAAATCATTGCCAATCTTACGCAACAACAATATACAAAATTAAAAACGTACAACGATGTTAA
ACAAATGAATCGACAAAATGTCGATGTAGAATCGATAGAAATTAATTTTCCATCAAACAAATTTAATCTAGGGTTTACAT
TTCAAGATACACCGGGTGTTGACTCTAACGTTGCAACGCATCAGTCGAGTACAGAGCAATTTATGTATACAAGTAACTTG
TTGTTTTATACAGTAGACTATAATCATGTCCAATCAGCGTTGAACTTTAAATTTATGAAACGTATTAATGAAGTTGGTAT
ACCAATTATTTTTGTGATTAATCAGATTGATAAACATAATGAAGAAGAAATTACATTTGAAACTTTTAAATCAAGAGTCG
AAAAATCAATCAAAGACTGGGATATCAAACTTCAAGATACTTATTACGTTTCAAAGTTTGATCATCCACAGAATGAAATT
GACAAACTTTCAAATTTTCTAGTATTTATGGATCAACATCGTGAATCAACAGAAGACTATGTTAATAGAACCATTCAATT
CATTACCGACGCACAATACATATACATTCAAAATGAAATGCAATCTATTCTTGACACCCTTCAAATTAATGAAGAACAAT
TCGAGGAAGCATATATTCAATTTCAACAAAATCAAGAAGTCAGCGCAGAAGCACAATTGCTCAATGACTCTAATCAATTA
TTTAATTATTTAAAACAGAAGCGTAAAGATATATTAGATAATGCTTATATCATGACGTACGATATGCGTGAATCTTTACG
GAATTATTTAGAAAGCATGGCAACTGATTTTAAAGTGAATGGATATTTTAATAAAAGGAAGAAAAAAGAAGAAGAACAAA
TCAAACGACTTAATGAGGCGACCACTCAATTGCAAGAGAAAGTTAATCAACAAGTACGACAACCACTTCGTGAAGATATG
TCATTTTTAACTAGATTCATAAATAAACATGCTGTGAATGAAAAAATACTAAATCAAGAATATGACGTCGTTCCGTCACT
TATATCAGAGCTATATCAAACTCAAACGAGCATTAGCAACACATACGTTTTAACATTTTCAGATGAAGTTATAAAAGCTT
TGAATAAAAAAATAGAAAATGAGTCAACACCACTATTTGAAGAAGCTGTCAATCATGTACAAGTTAATGAATTATCGAGT
GATGAAAATGAAGATAGGTATGAATATGATAGATACATTGAACTTAACACATTAAAGGATTCGCTTACATCCCACAACTA
CAAACATTACTATATCCATTTAGACGATTCTTTAGATAAATTAATTGGAAGAACAGAGACTCATTTTGAACTTAAACAAG
AAAATTCAACTGCTTATCATCGTAAACATGAGACACAACATCGTAACGAGTTTGTTACATCTAATCAAGATATTAAGCGT
GCATTAGATATCGTTAAAGATGTACCATTATTTGATCGCACTAAACAAGATATCACCGATACCATTCTGAGACTCGATAA
TCAAATAACAAAAGTAGGTGTTTTTGGTACATTTAGCGCAGGTAAAAGCAGCTTAATCAACGCTCTACTAGGTGATAACT
ATTTAGTTAGTTCTCCTAATCCAACAACAGCGGCAACGACGGAATTATCATATGGTAAAGAGAGTCAAATCACATTAAAA
TCTAAAGAGCAATTACTAGAGGAAGTTAATCATGTACTAGAATTTTATGAAATATCGTTTAACACCTTAGACAACTTTAT
TAAGAGCGATTTAGAGAAGTTAAAATCGAAACTAGAAAAGAACCAACTTGCATTTATTAGTGCAATTGAGAAACATTATG
AAATGTACACGTCAATGCTAGAACATTCACTTATACACACAGTATCGCTTGAAGAAATTAAAAAGTGGAGTGCCGAGGAT
GAGTATGCCACTTTCGTGAAAACTGTACACCTTAAGCTACCTTTAGATTGGCTTAAGGGTAAAATCATTATTGATTCACT
GGGTTTACATTCCAATAATCAAAGACACACGAATGAAACTGAACAAATTCTCACTTCTTCTGACCTTATTTTGTATGTAA
CTTACTTCAATCATTCATTTACAGATAACGACAAAGCCTTTATCGAACATATGAAAGATATGAATCAATTAAATGAAAAT
CAAGCTTTTAAAATGATAATTAATGCGGTTGACCTAGCTGAAGATAAACAGGATATACAAGCCGTTGAGGATTATGTTGC
AGATGCACTGGGGCAAGTTAACTTACACTCTGATATATATAGTGTTTCAAGTCGTCAAAGTTTAAATGGGAATAACATTG
GCATAAATGAATTAAGAGAAAGTATACAATACTTTGCAAAGGTTGAATCTAGAACAATTTTAGAGCAGCAGATGACTTAT
CAATTGCAACAAATGAATAACTCCTTTAAAAAAATGATTAAAGATTTTCACGATGACAACGCAAAATTATCAGCTAGACA
ACATAAATTAAATCACTATAAAAACCAAACCCTATTAAATCAAGAGTTGATTGATACAACTGCACAACGTACTTTCAATG
AAGTAGAAGAACAAGTATATCATCTAAATGAACGGTTAAAACTACAACTTTTAGATGAGGTTAAATCTGTGTTTAATAGT
CAGATGACACAAAATAACGACTTTAATGAGGAAAAGAAAATTTCAACTAAAATATATTTAGATCAAATTCATCAACGCTT
ATTCTTAGAGCAATCACTTATCACAGAAAGGATTAAAAAATATTTTAATTCACAACTAGAAGAACAAATCCTACCAGTCA
TGAAAAAGTTAAATCAGATTCATGTTATTATAAATGCAAAATTTAATGTTGAGCCATCACTGGTTGATACGGCGTTACTT
CAAATTGAACTTAATTCAATGTTGCAATCACTACCAAAACAGTTAACTAAACGTAAAATAGTTAATCCAAAGTCACAAAA
GGATATACAAGTACACATAGCTAATCAAACTCTTGAATTATTACAAGATGATTTGAACTCATTGCGCCGACAATTAAATG
ATTATATCCATGAGATGACTCAACTTGCCGAACATCAATTTCAAATGTTGGAGACATCCATTCAACAACAAATTGATGAG
TTACTTTCATTCACTATCGATGATACATTAATACAACAACTAGAATTGAAAACGACACAATTAGACAATATTTTATAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2G7I1Y4


Antitoxin

Source ID Structure

References


(1) Sadeghi Kalani Behrooz et al. (2018) Study of MazEF, sam, and phd-doc putative toxin-antitoxin systems in Staphylococcus epidermidis. Acta Microbiologica Et Immunologica Hungarica 65(1):81-91. [PubMed:29471693] in_silico


in_silico in silico analysis literature