Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3648755..3649233 Replicon chromosome
Accession NZ_CP028607
Organism Escherichia coli strain 143

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag C9E67_RS19550 Protein ID WP_001303876.1
Coordinates 3648946..3649233 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag C9E67_RS19545 Protein ID WP_000536233.1
Coordinates 3648755..3648946 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9E67_RS19510 3644159..3644929 - 771 WP_000450992.1 DUF1627 domain-containing protein -
C9E67_RS19515 3644951..3645697 - 747 WP_000788751.1 ATP-binding protein -
C9E67_RS19520 3645704..3646795 - 1092 WP_001205823.1 hypothetical protein -
C9E67_RS19525 3646874..3647329 + 456 WP_000273724.1 hypothetical protein -
C9E67_RS19530 3647536..3647961 - 426 WP_000693855.1 Rha family transcriptional regulator -
C9E67_RS19535 3647945..3648217 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
C9E67_RS19540 3648326..3648727 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
C9E67_RS19545 3648755..3648946 + 192 WP_000536233.1 hypothetical protein Antitoxin
C9E67_RS19550 3648946..3649233 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C9E67_RS19560 3649511..3649666 + 156 WP_000379575.1 DUF1391 family protein -
C9E67_RS19565 3649808..3650197 + 390 WP_000394511.1 hypothetical protein -
C9E67_RS19570 3650384..3650569 - 186 WP_001133046.1 hypothetical protein -
C9E67_RS19580 3651143..3651331 + 189 WP_000413705.1 cell division inhibition protein DicB -
C9E67_RS19585 3651328..3651519 + 192 WP_001098307.1 DUF1482 family protein -
C9E67_RS19590 3651613..3654084 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T101776 WP_001303876.1 NZ_CP028607:3648946-3649233 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T101776 NZ_CP028607:3648946-3649233 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT101776 WP_000536233.1 NZ_CP028607:3648755-3648946 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT101776 NZ_CP028607:3648755-3648946 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References