Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3500168..3500646 Replicon chromosome
Accession NZ_CP028598
Organism Escherichia coli strain 148

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag C9E70_RS18500 Protein ID WP_001303876.1
Coordinates 3500359..3500646 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag C9E70_RS18495 Protein ID WP_000536233.1
Coordinates 3500168..3500359 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9E70_RS18460 3495572..3496342 - 771 WP_000450992.1 DUF1627 domain-containing protein -
C9E70_RS18465 3496364..3497110 - 747 WP_000788745.1 ATP-binding protein -
C9E70_RS18470 3497117..3498208 - 1092 WP_001205823.1 hypothetical protein -
C9E70_RS18475 3498287..3498742 + 456 WP_000273724.1 hypothetical protein -
C9E70_RS18480 3498949..3499374 - 426 WP_000693855.1 Rha family transcriptional regulator -
C9E70_RS18485 3499358..3499630 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
C9E70_RS18490 3499739..3500140 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
C9E70_RS18495 3500168..3500359 + 192 WP_000536233.1 hypothetical protein Antitoxin
C9E70_RS18500 3500359..3500646 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C9E70_RS18510 3500924..3501079 + 156 WP_000379575.1 DUF1391 family protein -
C9E70_RS18515 3501221..3501610 + 390 WP_000394511.1 hypothetical protein -
C9E70_RS18520 3501797..3501982 - 186 WP_001133046.1 hypothetical protein -
C9E70_RS18530 3502556..3502744 + 189 WP_000413705.1 cell division inhibition protein DicB -
C9E70_RS18535 3502741..3502932 + 192 WP_001098307.1 DUF1482 family protein -
C9E70_RS18540 3503026..3505497 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T101671 WP_001303876.1 NZ_CP028598:3500359-3500646 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T101671 NZ_CP028598:3500359-3500646 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT101671 WP_000536233.1 NZ_CP028598:3500168-3500359 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT101671 NZ_CP028598:3500168-3500359 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References