Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type VIII Classification (family/domain) SdsR-RyeA/-
Location 1923066..1923337 Replicon chromosome
Accession NC_000913
Organism Escherichia coli str. K-12 substr. MG1655

Toxin (RNA)


Gene name SdsR
Locus tag -
Coordinates 1923104..1923207 (-)

Antitoxin (RNA)


Gene name RyeA
Locus tag -
Coordinates 1923066..1923337 (+)

Genomic Context

b1835b1836b1837--b1842b1843b1844b1838--b1839b1840b1841
Location: 1920223..1921662 (1440 bp)
Type: Others
Protein ID: NP_416349.2
Location: 1921780..1922016 (237 bp)
Type: Others
Protein ID: NP_416350.4
Location: 1922121..1922312 (192 bp)
Type: Others
Protein ID: NP_416351.2
Location: 1923066..1923337 (272 bp)
Type: Antitoxin
Protein ID: -
Location: 1925108..1925338 (231 bp)
Type: Others
Protein ID: NP_416356.1
Location: 1925440..1926096 (657 bp)
Type: Others
Protein ID: NP_416357.1
Location: 1926120..1926782 (663 bp)
Type: Others
Protein ID: NP_416358.1
Location: 1922313..1922969 (657 bp)
Type: Others
Protein ID: NP_416352.4
Location: 1923104..1923207 (104 bp)
Type: Toxin
Protein ID: -
Location: 1923365..1923706 (342 bp)
Type: Others
Protein ID: NP_416353.1
Location: 1923719..1924591 (873 bp)
Type: Others
Protein ID: NP_416354.1
Location: 1924595..1924969 (375 bp)
Type: Others
Protein ID: NP_416355.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
b18351920223..1921662+1440NP_416349.216S rRNA m(5)C1407 methyltransferase-
b18361921780..1922016+237NP_416350.4DUF1480 domain-containing protein YebV-
b18371922121..1922312+192NP_416351.2DUF1482 domain-containing protein YebW-
b18381922313..1922969-657NP_416352.4phosphoprotein phosphatase 1-
-1923066..1923337+272--Antitoxin
-1923104..1923207-104--Toxin
b18391923365..1923706-342NP_416353.1DUF2511 domain-containing protein YebY-
b18401923719..1924591-873NP_416354.1CopD family protein-
b18411924595..1924969-375NP_416355.1copper-binding protein-
b18421925108..1925338+231NP_416356.1DNA polymerase III subunit theta-
b18431925440..1926096+657NP_416357.1putative carbon-nitrogen hydrolase family protein YobB-
b18441926120..1926782+663NP_416358.1exonuclease X-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Sequences

Toxin        


Download         Length: 104 bp

>T10165 NC_000913:c1923207-1923104 [Escherichia coli str. K-12 substr. MG1655]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 272 bp

>AT10165 NC_000913:1923066-1923337 [Escherichia coli str. K-12 substr. MG1655]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Antitoxin

Download structure file

Antitoxin

Download structure file

References

(1) Jee Soo Choi et al. (2018) The small RNA, SdsR, acts as a novel type of toxin in Escherichia coli. RNA Biology 15(10):1319-1335. [PubMed:30293519] experimental


experimental experimental literature