Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | paaR-paaA-parE/- |
Location | 3500228..3500706 | Replicon | chromosome |
Accession | NZ_CP028596 | ||
Organism | Escherichia coli strain 149 |
Toxin (Protein)
Gene name | parE_1 | Uniprot ID | A0A891SFN9 |
Locus tag | C9E71_RS18500 | Protein ID | WP_001303876.1 |
Coordinates | 3500419..3500706 (+) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | paaA | Uniprot ID | Q8XD67 |
Locus tag | C9E71_RS18495 | Protein ID | WP_000536233.1 |
Coordinates | 3500228..3500419 (+) | Length | 64 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C9E71_RS18460 | 3495632..3496402 | - | 771 | WP_000450992.1 | DUF1627 domain-containing protein | - |
C9E71_RS18465 | 3496424..3497170 | - | 747 | WP_000788745.1 | ATP-binding protein | - |
C9E71_RS18470 | 3497177..3498268 | - | 1092 | WP_001205823.1 | hypothetical protein | - |
C9E71_RS18475 | 3498347..3498802 | + | 456 | WP_000273724.1 | hypothetical protein | - |
C9E71_RS18480 | 3499009..3499434 | - | 426 | WP_000693855.1 | Rha family transcriptional regulator | - |
C9E71_RS18485 | 3499418..3499690 | - | 273 | WP_000887453.1 | helix-turn-helix domain-containing protein | - |
C9E71_RS18490 | 3499799..3500200 | + | 402 | WP_000986592.1 | helix-turn-helix domain-containing protein | - |
C9E71_RS18495 | 3500228..3500419 | + | 192 | WP_000536233.1 | hypothetical protein | Antitoxin |
C9E71_RS18500 | 3500419..3500706 | + | 288 | WP_001303876.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
C9E71_RS18510 | 3500984..3501139 | + | 156 | WP_000379575.1 | DUF1391 family protein | - |
C9E71_RS18515 | 3501281..3501670 | + | 390 | WP_000394511.1 | hypothetical protein | - |
C9E71_RS18520 | 3501857..3502042 | - | 186 | WP_001133046.1 | hypothetical protein | - |
C9E71_RS18530 | 3502616..3502804 | + | 189 | WP_000413705.1 | cell division inhibition protein DicB | - |
C9E71_RS18535 | 3502801..3502992 | + | 192 | WP_001098307.1 | DUF1482 family protein | - |
C9E71_RS18540 | 3503086..3505557 | + | 2472 | WP_000034474.1 | exonuclease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10978.84 Da Isoelectric Point: 10.1360
>T101636 WP_001303876.1 NZ_CP028596:3500419-3500706 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI
Download Length: 288 bp
>T101636 NZ_CP028596:3500419-3500706 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7025.80 Da Isoelectric Point: 4.0270
>AT101636 WP_000536233.1 NZ_CP028596:3500228-3500419 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE
Download Length: 192 bp
>AT101636 NZ_CP028596:3500228-3500419 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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