Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/- |
| Location | 125..742 | Replicon | Plasmid RK2 (from Klebsiella pneumoniae) parD and parE genes |
| Accession | L05507 | ||
| Organism | Plasmid DEFINITION | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | - | Protein ID | - |
| Coordinates | 431..742 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | - |
| Locus tag | - | Protein ID | - |
| Coordinates | 125..434 (+) | Length | 103.33333333333 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| - | 125..434 | + | 310 | - | - | Antitoxin |
| Locus_1 | 431..742 | + | 312 | AAA92775.1 | - | Toxin |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 11715.73 Da Isoelectric Point: 9.1036
>T10163 - L05507:431-742 [Plasmid RK2]
MTAYILTAEAEADLRGIIRYTRREWGAAQVRRYIAKLEQGIARLAAGEGPFKDMSELFPALRMARCEHHYVFCLPRAGEP
ALVVAILHERMDLMTRLADRLKG
MTAYILTAEAEADLRGIIRYTRREWGAAQVRRYIAKLEQGIARLAAGEGPFKDMSELFPALRMARCEHHYVFCLPRAGEP
ALVVAILHERMDLMTRLADRLKG
Download Length: 312 bp
>T10163 L05507:431-742 [Plasmid RK2]
TTGACGGCCTACATCCTCACGGCTGAGGCCGAAGCCGATCTACGCGGCATCATCCGCTACACGCGCCGGGAGTGGGGCGC
GGCGCAGGTGCGCCGCTATATCGCTAAGCTGGAACAGGGCATAGCCAGGCTTGCCGCCGGCGAAGGCCCGTTTAAGGACA
TGAGCGAACTCTTTCCCGCGCTGCGGATGGCCCGCTGCGAACACCACTACGTTTTTTGCCTGCCGCGTGCGGGCGAACCC
GCGTTGGTCGTGGCGATCCTGCATGAGCGCATGGACCTCATGACGCGACTTGCCGACAGGCTCAAGGGCTGA
TTGACGGCCTACATCCTCACGGCTGAGGCCGAAGCCGATCTACGCGGCATCATCCGCTACACGCGCCGGGAGTGGGGCGC
GGCGCAGGTGCGCCGCTATATCGCTAAGCTGGAACAGGGCATAGCCAGGCTTGCCGCCGGCGAAGGCCCGTTTAAGGACA
TGAGCGAACTCTTTCCCGCGCTGCGGATGGCCCGCTGCGAACACCACTACGTTTTTTGCCTGCCGCGTGCGGGCGAACCC
GCGTTGGTCGTGGCGATCCTGCATGAGCGCATGGACCTCATGACGCGACTTGCCGACAGGCTCAAGGGCTGA
Antitoxin
Download Length: 103.33333333333 a.a. Molecular weight: 10907.14 Da Isoelectric Point: 11.6555
>AT10163 - L05507:125-434 [Plasmid RK2]
PHAHICANVVTCILWRLSNEPPDNRHDGPAAPEPESPGRLAGQDHAIRPRTSVPRRCRSGMAGTENHAGEPHQRWACRQG
VHQERRRNSRTQRGSRL
PHAHICANVVTCILWRLSNEPPDNRHDGPAAPEPESPGRLAGQDHAIRPRTSVPRRCRSGMAGTENHAGEPHQRWACRQG
VHQERRRNSRTQRGSRL
Download Length: 310 bp
>AT10163 L05507:125-434 [Plasmid RK2]
TAGCCTCACGCCCACATATGTGCTAATGTGGTTACGTGTATTTTATGGAGGTTATCCAATGAGCCGCCTGACAATCGACA
TGACGGACCAGCAGCACCAGAGCCTGAAAGCCCTGGCCGCCTTGCAGGGCAAGACCATTAAGCAATACGCCCTCGAACGT
CTGTTCCCCGGTGACGCTGATGCCGATCAGGCATGGCAGGAACTGAAAACCATGCTGGGGAACCGCATCAACGATGGGCT
TGCCGGCAAGGTGTCCACCAAGAGCGTCGGCGAAATTCTTGATGAAGAACTCAGCGGGGATCGCGCTTGA
TAGCCTCACGCCCACATATGTGCTAATGTGGTTACGTGTATTTTATGGAGGTTATCCAATGAGCCGCCTGACAATCGACA
TGACGGACCAGCAGCACCAGAGCCTGAAAGCCCTGGCCGCCTTGCAGGGCAAGACCATTAAGCAATACGCCCTCGAACGT
CTGTTCCCCGGTGACGCTGATGCCGATCAGGCATGGCAGGAACTGAAAACCATGCTGGGGAACCGCATCAACGATGGGCT
TGCCGGCAAGGTGTCCACCAAGAGCGTCGGCGAAATTCTTGATGAAGAACTCAGCGGGGATCGCGCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|
References
(1) Andrzej Dubiel et al. (2018) ClpAP protease is a universal factor that activates the parDE toxin-antitoxin system from a broad host range RK2 plasmid. Scientific Reports 8(1):15287. [PubMed:30327496]