101530

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5198347..5198955 Replicon chromosome
Accession NZ_CP028584
Organism Pseudomonas aeruginosa strain WCHPA075019

Toxin (Protein)


Gene name PfiT Uniprot ID -
Locus tag DBA97_RS24540 Protein ID WP_016263850.1
Coordinates 5198347..5198694 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag DBA97_RS24545 Protein ID WP_003114155.1
Coordinates 5198704..5198955 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBA97_RS24510 5193706..5193978 + 273 WP_019725834.1 cysteine-rich CWC family protein -
DBA97_RS24515 5193978..5194670 + 693 WP_003098362.1 16S rRNA pseudouridine(516) synthase -
DBA97_RS24520 5194806..5195849 + 1044 WP_003098363.1 L,D-transpeptidase -
DBA97_RS24525 5195929..5196666 + 738 WP_003114158.1 murein L,D-transpeptidase catalytic domain family protein -
DBA97_RS24530 5197118..5198020 + 903 WP_003123042.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
DBA97_RS24540 5198347..5198694 - 348 WP_016263850.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DBA97_RS24545 5198704..5198955 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DBA97_RS24550 5199169..5200152 - 984 WP_019725833.1 tyrosine-type recombinase/integrase -
DBA97_RS24555 5200152..5201444 - 1293 WP_003115206.1 hypothetical protein -
DBA97_RS24560 5201703..5202965 - 1263 WP_019725831.1 hypothetical protein -
DBA97_RS24565 5202967..5203317 - 351 WP_019725830.1 DUF2523 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 5198347..5220490 22143


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-100)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 116 a.a.        Molecular weight: 13046.85 Da        Isoelectric Point: 4.4212

>T101530 WP_016263850.1 NZ_CP028584:c5198694-5198347 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLVPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T101530 NZ_CP028584:c5198694-5198347 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGTTCCATTCCA
AGGTGAACAGGCTGCATTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGTGGCAGTGATCTTGGTTTTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT101530 WP_003114155.1 NZ_CP028584:c5198955-5198704 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT101530 NZ_CP028584:c5198955-5198704 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACTTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References