Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4885459..4885975 Replicon chromosome
Accession NZ_CP028583
Organism Klebsiella pneumoniae strain WCHKP36

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag CEA75_RS26195 Protein ID WP_002886902.1
Coordinates 4885459..4885743 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag CEA75_RS26200 Protein ID WP_002886901.1
Coordinates 4885733..4885975 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEA75_RS26175 4880943..4881251 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
CEA75_RS26180 4881512..4882255 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
CEA75_RS26185 4882612..4884750 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
CEA75_RS26190 4884991..4885455 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CEA75_RS26195 4885459..4885743 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CEA75_RS26200 4885733..4885975 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CEA75_RS26205 4886053..4887963 - 1911 WP_004152270.1 BglG family transcription antiterminator -
CEA75_RS26210 4887986..4889140 - 1155 WP_002886900.1 lactonase family protein -
CEA75_RS26215 4889206..4889946 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T101521 WP_002886902.1 NZ_CP028583:c4885743-4885459 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T101521 NZ_CP028583:c4885743-4885459 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT101521 WP_002886901.1 NZ_CP028583:c4885975-4885733 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT101521 NZ_CP028583:c4885975-4885733 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References