Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4165664..4166283 Replicon chromosome
Accession NZ_CP028583
Organism Klebsiella pneumoniae strain WCHKP36

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag CEA75_RS22600 Protein ID WP_002892050.1
Coordinates 4166065..4166283 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag CEA75_RS22595 Protein ID WP_002892066.1
Coordinates 4165664..4166038 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEA75_RS22585 4160816..4162009 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CEA75_RS22590 4162032..4165178 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
CEA75_RS22595 4165664..4166038 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
CEA75_RS22600 4166065..4166283 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
CEA75_RS22605 4166442..4167008 + 567 WP_002892030.1 maltose O-acetyltransferase -
CEA75_RS22610 4167141..4167611 + 471 WP_002892026.1 YlaC family protein -
CEA75_RS22615 4167586..4169037 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
CEA75_RS22620 4169138..4169836 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
CEA75_RS22625 4169833..4169973 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
CEA75_RS22630 4169973..4170236 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T101519 WP_002892050.1 NZ_CP028583:4166065-4166283 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T101519 NZ_CP028583:4166065-4166283 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT101519 WP_002892066.1 NZ_CP028583:4165664-4166038 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT101519 NZ_CP028583:4165664-4166038 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References