Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 38809..39337 Replicon plasmid pOXA58_005046
Accession NZ_CP028573
Organism Acinetobacter pittii strain WCHAP005046

Toxin (Protein)


Gene name relE Uniprot ID N9N871
Locus tag DBQ26_RS01065 Protein ID WP_000221358.1
Coordinates 38809..39102 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9NWT9
Locus tag DBQ26_RS01070 Protein ID WP_000246755.1
Coordinates 39092..39337 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBQ26_RS01035 34078..34335 + 258 WP_004726728.1 hypothetical protein -
DBQ26_RS01040 35255..35560 + 306 WP_000366814.1 helix-turn-helix domain-containing protein -
DBQ26_RS01045 35560..36825 + 1266 WP_000934716.1 HipA domain-containing protein -
DBQ26_RS01050 37382..37828 - 447 Protein_32 Tn3 family transposase -
DBQ26_RS01055 37893..38597 + 705 WP_001067858.1 IS6-like element IS26 family transposase -
DBQ26_RS01065 38809..39102 - 294 WP_000221358.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DBQ26_RS01070 39092..39337 - 246 WP_000246755.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DBQ26_RS01075 39853..41328 + 1476 WP_000052512.1 ABC-F type ribosomal protection protein Msr(E) -
DBQ26_RS01080 41384..42268 + 885 WP_000155092.1 Mph(E) family macrolide 2'-phosphotransferase -
DBQ26_RS01085 42438..42752 - 315 WP_038350244.1 BrnA antitoxin family protein -
DBQ26_RS01090 42715..43026 - 312 WP_063454728.1 BrnT family toxin -
DBQ26_RS01095 43245..43850 - 606 WP_000447788.1 LysE family translocator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid msr(E) / mph(E) / blaOXA-58 - 1..61751 61751
- inside IScluster/Tn msr(E) / mph(E) / blaOXA-58 - 37352..47067 9715


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11292.52 Da        Isoelectric Point: 10.4753

>T101465 WP_000221358.1 NZ_CP028573:c39102-38809 [Acinetobacter pittii]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T101465 NZ_CP028573:c39102-38809 [Acinetobacter pittii]
ATGACTTATAAGCTTTTACGTCACAAGGACTTTACAGCAGAATGGGAAAAACTCCCTGTTGCTATACGAGATCAATTTAA
AAAGAAACTAGCCAAAGTCATAGAGCAGCCACATATTCCAAAGAATATGCTTAGAGGCGATCTTGCAGGTTGCTATAAAA
TCAAATTATTAAAAGCTGGTGTCCGACTTGTCTATCAAGTTAAAGATGATCAGGTAGTTATCCTGCTCATTACCGTCGGA
AAACGAGCTGATAGCATAGTTTATGACGAAGCGAAAAAGCGAATTAAAGACTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9249.64 Da        Isoelectric Point: 4.3142

>AT101465 WP_000246755.1 NZ_CP028573:c39337-39092 [Acinetobacter pittii]
MATVNFRIDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT101465 NZ_CP028573:c39337-39092 [Acinetobacter pittii]
ATGGCTACTGTTAACTTCAGGATCGATGAAGCCCTTAAAGAAAAATCTTATTCAATCCTTAAAGAGCAAGGTATTGCACC
TACTGATTTCTTCACTAGTATTCTTGAGTATGTTGCTACGACTGGGAAACTGCCTGTCAAAAAAGCTTTGCTTTCGGAAG
AAGATGAAGAATTATTAGCTCTTGTCCGTAAGCGCATTAATGATCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A1RKP4

Antitoxin

Source ID Structure
AlphaFold DB A0A6A1RJ80

References