Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2749436..2749964 Replicon chromosome
Accession NZ_CP028561
Organism Acinetobacter sp. WCHA45

Toxin (Protein)


Gene name relE Uniprot ID N9N871
Locus tag CDG55_RS14580 Protein ID WP_000221358.1
Coordinates 2749436..2749729 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9NWT9
Locus tag CDG55_RS14585 Protein ID WP_000246755.1
Coordinates 2749719..2749964 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDG55_RS14565 (CDG55_14555) 2746288..2747040 + 753 WP_087537530.1 serine protease -
CDG55_RS14570 (CDG55_14560) 2747062..2747947 + 886 Protein_2541 IS3 family transposase -
CDG55_RS14575 (CDG55_14565) 2747985..2748971 - 987 Protein_2542 IS110 family transposase -
CDG55_RS14580 (CDG55_14570) 2749436..2749729 - 294 WP_000221358.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CDG55_RS14585 (CDG55_14575) 2749719..2749964 - 246 WP_000246755.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CDG55_RS14590 (CDG55_14580) 2750265..2751788 + 1524 WP_087536625.1 TerC family protein -
CDG55_RS14595 (CDG55_14585) 2752272..2752469 + 198 WP_111313931.1 transposase -
CDG55_RS14600 (CDG55_14590) 2752686..2753183 + 498 WP_087536679.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11292.52 Da        Isoelectric Point: 10.4753

>T101462 WP_000221358.1 NZ_CP028561:c2749729-2749436 [Acinetobacter sp. WCHA45]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T101462 NZ_CP028561:c2749729-2749436 [Acinetobacter sp. WCHA45]
ATGACTTATAAGCTTTTACGTCACAAGGACTTTACAGCAGAATGGGAAAAACTCCCTGTTGCTATACGAGATCAATTTAA
AAAGAAACTAGCCAAAGTCATAGAGCAGCCACATATTCCAAAGAATATGCTTAGAGGCGATCTTGCGGGTTGCTATAAAA
TCAAATTATTAAAAGCTGGTGTCCGACTTGTCTATCAAGTTAAAGATGATCAGGTAGTTATCCTGCTCATTACCGTCGGA
AAACGAGCTGATAGCATAGTTTATGACGAAGCGAAAAAGCGAATTAAAGACTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9249.64 Da        Isoelectric Point: 4.3142

>AT101462 WP_000246755.1 NZ_CP028561:c2749964-2749719 [Acinetobacter sp. WCHA45]
MATVNFRIDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT101462 NZ_CP028561:c2749964-2749719 [Acinetobacter sp. WCHA45]
ATGGCTACTGTTAACTTCAGGATCGATGAAGCCCTTAAAGAAAAATCTTATTCAATCCTTAAAGAGCAAGGTATTGCACC
TACGGATTTCTTCACTAGTATTCTTGAGTATGTTGCTACGACTGGGAAACTGCCTGTCAAAAAAGCTTTGCTTTCGGAAG
AAGATGAAGAACTATTAGCTCTTGTCCGTAAGCGGATTAATGATCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A1RKP4

Antitoxin

Source ID Structure
AlphaFold DB A0A6A1RJ80

References