Detailed information of TA system TA101461

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-RelB
• Location: 2741665..2742178
• Replicon: chromosome
• Accession: NZ_CP028561
• Organism: Acinetobacter sp. WCHA45

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: CDG55_RS14540
• Protein ID: WP_087536686.1
• Coordinates: 2741915..2742178 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: S7WSW9
• Locus tag: CDG55_RS14535
• Protein ID: WP_000557943.1
• Coordinates: 2741665..2741928 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDG55_RS14520 (CDG55_14510)	2737066..2737347	+	282	WP_087536688.1	DUF4236 domain-containing protein	-
CDG55_RS14525 (CDG55_14515)	2737603..2737884	+	282	WP_111313930.1	hypothetical protein	-
CDG55_RS14530 (CDG55_14520)	2737902..2741249	-	3348	WP_087536687.1	DEAD/DEAH box helicase	-
CDG55_RS14535 (CDG55_14525)	2741665..2741928	+	264	WP_000557943.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CDG55_RS14540 (CDG55_14530)	2741915..2742178	+	264	WP_087536686.1	Txe/YoeB family addiction module toxin	Toxin
CDG55_RS14545 (CDG55_14535)	2742250..2742405	-	156	Protein_2536	IS5/IS1182 family transposase	-
CDG55_RS14550 (CDG55_14540)	2742451..2742670	-	220	Protein_2537	transposase	-
CDG55_RS14555 (CDG55_14545)	2742746..2743793	+	1048	Protein_2538	IS3 family transposase	-
CDG55_RS14560 (CDG55_14550)	2743866..2746193	+	2328	WP_087537531.1	hypothetical protein	-
CDG55_RS14565 (CDG55_14555)	2746288..2747040	+	753	WP_087537530.1	serine protease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10665.08 Da
• Isoelectric Point: 7.1332

>T101461 WP_087536686.1 NZ_CP028561:2741915-2742178 [Acinetobacter sp. WCHA45]
MTSRNVEWTENAWDEYIYWQTQDIKILKRINTLIRECQRTPFEGTGKPEPLKANLSGFWSRRIDEKHRLVYEVTDERISI
VQCWFHY

Nucleotide

• Length: 264 bp

>T101461 NZ_CP028561:2741915-2742178 [Acinetobacter sp. WCHA45]
ATGACGAGTCGTAATGTCGAATGGACTGAAAATGCCTGGGATGAATATATCTATTGGCAAACACAGGATATAAAGATACT
CAAACGTATCAATACCTTAATCAGAGAATGTCAAAGAACACCCTTTGAAGGAACTGGAAAACCAGAACCTTTAAAAGCAA
ATCTTTCAGGATTCTGGAGCCGTAGAATTGATGAGAAGCATAGATTAGTTTATGAAGTGACGGATGAACGAATTTCCATT
GTTCAATGTTGGTTCCATTACTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9841.04 Da
• Isoelectric Point: 5.5940

>AT101461 WP_000557943.1 NZ_CP028561:2741665-2741928 [Acinetobacter sp. WCHA45]
MHVFTYTDARNNLKSVLDKVIDDADVAFITRKEGGHAVVMGQDHYDSLMETLYLLSSPNNTTRLNESIAQLRAGKTKQRE
LIKDDES

Nucleotide

• Length: 264 bp

>AT101461 NZ_CP028561:2741665-2741928 [Acinetobacter sp. WCHA45]
ATGCATGTATTTACATATACAGACGCACGTAACAACTTAAAATCTGTTTTAGATAAAGTTATTGATGATGCAGATGTCGC
TTTCATTACAAGAAAAGAAGGCGGTCATGCTGTAGTAATGGGACAAGATCATTACGACAGTTTAATGGAAACGTTGTATC
TCCTTTCATCTCCAAATAATACCACTCGTTTAAACGAATCAATTGCTCAATTACGCGCAGGTAAAACCAAACAAAGAGAG
TTGATTAAAGATGACGAGTCGTAA

Structures

Antitoxin

• AlphaFold DB: S7WSW9