Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 188..9982 Replicon plasmid p3_020143
Accession NZ_CP028545
Organism Klebsiella pneumoniae subsp. pneumoniae strain SCKP020143

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag CLQ46_RS01560 Protein ID WP_071177730.1
Coordinates 188..502 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag CLQ46_RS01555 Protein ID WP_000093040.1
Coordinates 9982..200 (+) Length -3260.3333333333 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLQ46_RS01560 188..502 + 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CLQ46_RS01565 666..1094 + 429 WP_001140599.1 hypothetical protein -
CLQ46_RS01570 1120..1299 + 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
CLQ46_RS01575 1326..1856 - 531 WP_071177729.1 hypothetical protein -
CLQ46_RS01580 1863..2594 - 732 WP_071177728.1 replication-relaxation family protein -
CLQ46_RS01585 2594..4558 - 1965 WP_071177727.1 TraM recognition domain-containing protein -
CLQ46_RS01590 4586..4891 - 306 WP_071994323.1 hypothetical protein -
CLQ46_RS01595 6042..6191 - 150 WP_032440454.1 colicin release lysis protein -
CLQ46_RS01600 6276..6533 - 258 WP_032440455.1 cloacin -
CLQ46_RS01605 6543..8228 - 1686 WP_032440457.1 cloacin -
CLQ46_RS01610 8555..8800 + 246 WP_032440458.1 hypothetical protein -
CLQ46_RS01615 9074..9445 + 372 WP_001237044.1 cell envelope integrity protein TolA -
CLQ46_RS01620 9442..9648 + 207 Protein_13 TonB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10060 10060


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T101405 WP_071177730.1 NZ_CP028545:188-502 [Klebsiella pneumoniae subsp. pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

>T101405 NZ_CP028545:188-502 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: -3260.3333333333 a.a.        Molecular weight: 17270.35 Da        Isoelectric Point: 5.7254

>AT101405 WP_000093040.1 NZ_CP028545:9982-200 [Klebsiella pneumoniae subsp. pneumoniae]

Download         Length: -9781 bp

>AT101405 NZ_CP028545:9982-200 [Klebsiella pneumoniae subsp. pneumoniae]

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References