Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4194967..4195621 Replicon chromosome
Accession NZ_CP028542
Organism Klebsiella pneumoniae strain WCHKP2

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag CAY63_RS22755 Protein ID WP_004144731.1
Coordinates 4194967..4195374 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag CAY63_RS22760 Protein ID WP_002916312.1
Coordinates 4195355..4195621 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAY63_RS22735 4190967..4192700 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
CAY63_RS22740 4192706..4193419 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CAY63_RS22745 4193442..4194338 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
CAY63_RS22750 4194439..4194960 + 522 WP_002916308.1 flavodoxin FldB -
CAY63_RS22755 4194967..4195374 - 408 WP_004144731.1 protein YgfX Toxin
CAY63_RS22760 4195355..4195621 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
CAY63_RS22765 4195867..4196850 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
CAY63_RS22770 4197001..4197660 - 660 WP_002916317.1 hemolysin III family protein -
CAY63_RS22775 4197824..4198135 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
CAY63_RS22780 4198185..4198913 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
CAY63_RS22785 4199032..4200465 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T101398 WP_004144731.1 NZ_CP028542:c4195374-4194967 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T101398 NZ_CP028542:c4195374-4194967 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT101398 WP_002916312.1 NZ_CP028542:c4195621-4195355 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT101398 NZ_CP028542:c4195621-4195355 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References