Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4692389..4693005 Replicon chromosome
Accession NZ_CP028538
Organism Enterobacter hormaechei strain SCEH020042

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DBP88_RS25035 Protein ID WP_080346796.1
Coordinates 4692389..4692760 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A9E7BIL4
Locus tag DBP88_RS25040 Protein ID WP_023298920.1
Coordinates 4692763..4693005 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBP88_RS25020 4689889..4690791 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
DBP88_RS25025 4690788..4691423 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
DBP88_RS25030 4691420..4692349 + 930 WP_023305104.1 formate dehydrogenase accessory protein FdhE -
DBP88_RS25035 4692389..4692760 - 372 WP_080346796.1 type II toxin-antitoxin system VapC family toxin Toxin
DBP88_RS25040 4692763..4693005 - 243 WP_023298920.1 ribbon-helix-helix protein, CopG family Antitoxin
DBP88_RS25045 4693205..4694125 + 921 WP_023305106.1 alpha/beta hydrolase -
DBP88_RS25050 4694134..4695075 - 942 WP_023305107.1 fatty acid biosynthesis protein FabY -
DBP88_RS25055 4695120..4695557 - 438 WP_023305108.1 D-tyrosyl-tRNA(Tyr) deacylase -
DBP88_RS25060 4695554..4696435 - 882 WP_023298923.1 virulence factor BrkB family protein -
DBP88_RS25065 4696429..4697028 - 600 WP_023305109.1 glucose-1-phosphatase -
DBP88_RS25070 4697147..4697947 - 801 WP_023305110.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13668.73 Da        Isoelectric Point: 6.2151

>T101379 WP_080346796.1 NZ_CP028538:c4692760-4692389 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEAKTAAVMEAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL

Download         Length: 372 bp

>T101379 NZ_CP028538:c4692760-4692389 [Enterobacter hormaechei]
ATGGAGCACATGGCTGTGTTTGACACCAATATCCTCATCGATCTTTTTAATAACCACGTTGAGGCTGCGGATGCGATCGA
TCGCACAGCTTCGCATCGTGCCATTAGCCTCATCACATGGATGGAAGTAATGGTGGGCGCTCGCAGGCACGGTCAAGAAG
CAAAAACGGCAGCCGTGATGGAGGCCTTTGAAATTATTGATATAACAAGGGAAATTGCTGAAAGAAGCGTATTACTTCGC
GAACAGCACGGGATGAAGCTTCCTGACGCCATTATTCTGGCTACTGCTCAGAGCAGAAGCTGTCCGTTAATTTCGCGCAA
TACGAAAGACTTTTCGGGTATTGCTGGGGTCGTTTCACCTTACCACCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9467.74 Da        Isoelectric Point: 4.3775

>AT101379 WP_023298920.1 NZ_CP028538:c4693005-4692763 [Enterobacter hormaechei]
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT101379 NZ_CP028538:c4693005-4692763 [Enterobacter hormaechei]
ATGAGTCTTTTGGCGGACCTTACTATGGGCAGAATACTGATCGATTTGTCTGATGACGTGATTCAACGACTGGATAACCT
GAAGCAGTTGCGCAACCGGCCGCGCGCCGAACTGCTGCGGGAAGCCATAGAACTGTATCTCGACCAGCAGAATTCATCGG
TTATCCGCGAAGCGCTTGGCCTGTGGGGAAATCAGCAGGAAGATGGGCTTGAGTACGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References