Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 615312..615839 Replicon chromosome
Accession NZ_CP028538
Organism Enterobacter hormaechei strain SCEH020042

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag DBP88_RS05115 Protein ID WP_108168541.1
Coordinates 615564..615839 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag DBP88_RS05110 Protein ID WP_108168540.1
Coordinates 615312..615560 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBP88_RS05075 611172..611849 + 678 WP_108168534.1 hypothetical protein -
DBP88_RS05080 611949..612767 + 819 WP_108168535.1 DUF945 domain-containing protein -
DBP88_RS05085 612837..613310 + 474 WP_108168536.1 DNA repair protein RadC -
DBP88_RS05090 613321..613542 + 222 WP_108168537.1 DUF987 family protein -
DBP88_RS05095 613566..613910 + 345 Protein_555 type IV toxin-antitoxin system YeeU family antitoxin -
DBP88_RS05100 613946..614287 + 342 WP_108168538.1 TA system toxin CbtA family protein -
DBP88_RS05105 614402..615235 + 834 WP_108168539.1 DUF4942 domain-containing protein -
DBP88_RS05110 615312..615560 + 249 WP_108168540.1 ribbon-helix-helix domain-containing protein Antitoxin
DBP88_RS05115 615564..615839 + 276 WP_108168541.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DBP88_RS05120 615955..616752 + 798 WP_108168542.1 helix-turn-helix transcriptional regulator -
DBP88_RS05125 617047..618318 + 1272 WP_048962080.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage fosA - 613946..649863 35917


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-42)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10985.33 Da        Isoelectric Point: 4.8991

>T101366 WP_108168541.1 NZ_CP028538:615564-615839 [Enterobacter hormaechei]
MEIYWTLKAQDDLERIYRFALQYSRQHADDVLERLITGCAGLAAHPAIGVQQSRYEPREVRKVLFDDYEVHYELRDNDIY
IVDLWHTKEER

Download         Length: 276 bp

>T101366 NZ_CP028538:615564-615839 [Enterobacter hormaechei]
ATGGAAATTTACTGGACGCTTAAAGCTCAGGATGACCTGGAGCGTATCTACCGTTTCGCCCTTCAGTACAGCCGCCAGCA
CGCCGATGATGTTTTGGAACGCCTGATTACTGGCTGCGCTGGCCTTGCAGCGCATCCGGCAATTGGTGTACAGCAGTCTC
GGTATGAACCTCGGGAAGTCCGAAAAGTGTTATTTGATGATTACGAGGTTCACTACGAACTTCGTGACAATGACATCTAT
ATCGTGGATCTCTGGCATACCAAAGAAGAACGTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8972.25 Da        Isoelectric Point: 7.2042

>AT101366 WP_108168540.1 NZ_CP028538:615312-615560 [Enterobacter hormaechei]
MGSLTKQTISAQIPVELAAAVENLAIELDRSKSWIIKEALTSMLAERERRHQSIQAGLADVDAGRVVSHSDVVDFANRLK
KS

Download         Length: 249 bp

>AT101366 NZ_CP028538:615312-615560 [Enterobacter hormaechei]
ATGGGTTCGCTTACTAAACAAACCATCAGCGCACAGATACCCGTTGAATTGGCTGCTGCTGTTGAAAATCTGGCAATTGA
GTTGGACCGTTCTAAGAGCTGGATTATTAAAGAAGCGTTGACCAGTATGCTGGCCGAAAGAGAACGGCGTCATCAGAGCA
TTCAGGCCGGTCTTGCCGATGTGGATGCCGGTCGCGTGGTGAGCCACTCGGACGTGGTGGATTTTGCTAATCGCTTAAAG
AAATCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References