Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 230378..230904 Replicon plasmid pQnrB4_020042
Accession NZ_CP028537
Organism Enterobacter hormaechei strain SCEH020042

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag DBP88_RS01570 Protein ID WP_000323025.1
Coordinates 230378..230665 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag DBP88_RS01575 Protein ID WP_000534858.1
Coordinates 230665..230904 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBP88_RS01535 225948..226124 - 177 WP_001371930.1 hypothetical protein -
DBP88_RS01540 226635..227579 + 945 WP_000778029.1 DUF5417 domain-containing protein -
DBP88_RS01545 227675..228277 + 603 WP_012695474.1 hypothetical protein -
DBP88_RS01550 228337..228687 + 351 WP_000743059.1 hypothetical protein -
DBP88_RS01555 228734..228937 + 204 WP_001015183.1 hypothetical protein -
DBP88_RS01560 229219..229539 + 321 WP_000332796.1 hypothetical protein -
DBP88_RS01565 230148..230306 - 159 WP_001447866.1 type I toxin-antitoxin system Hok family toxin -
DBP88_RS01570 230378..230665 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
DBP88_RS01575 230665..230904 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
DBP88_RS01585 231167..232090 - 924 WP_000167917.1 cation diffusion facilitator family transporter -
DBP88_RS01590 232290..232862 - 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
DBP88_RS01595 233338..234576 - 1239 WP_000219087.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul2 / floR / oqxA / oqxB / dfrA17 / aph(3'')-Ib / aph(6)-Id / aph(3')-Ia / tet(D) / sul1 / blaDHA-1 / qnrB4 / qacE / ere(A) / aac(6')-IIc - 1..328828 328828


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T101363 WP_000323025.1 NZ_CP028537:c230665-230378 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T101363 NZ_CP028537:c230665-230378 [Enterobacter hormaechei]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT101363 WP_000534858.1 NZ_CP028537:c230904-230665 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT101363 NZ_CP028537:c230904-230665 [Enterobacter hormaechei]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References