Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4425802..4426422 Replicon chromosome
Accession NZ_CP028520
Organism Lelliottia sp. WB101

Toxin (Protein)


Gene name Hha Uniprot ID A0A2S5C408
Locus tag DAI21_RS21440 Protein ID WP_012016344.1
Coordinates 4426204..4426422 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag DAI21_RS21435 Protein ID WP_100777374.1
Coordinates 4425802..4426176 (+) Length 125 a.a.

Genomic Context

DAI21_RS21425DAI21_RS21430DAI21_RS21435DAI21_RS21440DAI21_RS21445DAI21_RS21450DAI21_RS21460DAI21_RS21455DAI21_RS21465DAI21_RS21470
Location: 4420928..4422121 (1194 bp)
Type: Others
Protein ID: WP_100777372.1
Location: 4422144..4425290 (3147 bp)
Type: Others
Protein ID: WP_100777373.1
Location: 4425802..4426176 (375 bp)
Type: Antitoxin
Protein ID: WP_100777374.1
Location: 4426204..4426422 (219 bp)
Type: Toxin
Protein ID: WP_012016344.1
Location: 4426638..4427189 (552 bp)
Type: Others
Protein ID: WP_107704127.1
Location: 4427307..4427774 (468 bp)
Type: Others
Protein ID: WP_100777376.1
Location: 4429304..4430014 (711 bp)
Type: Others
Protein ID: WP_107704129.1
Location: 4427746..4429203 (1458 bp)
Type: Others
Protein ID: WP_107704128.1
Location: 4430011..4430151 (141 bp)
Type: Others
Protein ID: WP_005125190.1
Location: 4430154..4430414 (261 bp)
Type: Others
Protein ID: WP_095281030.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DAI21_RS214254420928..4422121+1194WP_100777372.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-
DAI21_RS214304422144..4425290+3147WP_100777373.1multidrug efflux RND transporter permease subunit AcrB-
DAI21_RS214354425802..4426176+375WP_100777374.1Hha toxicity modulator TomBAntitoxin
DAI21_RS214404426204..4426422+219WP_012016344.1hemolysin expression modulator HhaToxin
DAI21_RS214454426638..4427189+552WP_107704127.1maltose O-acetyltransferase-
DAI21_RS214504427307..4427774+468WP_100777376.1hypothetical protein-
DAI21_RS214554427746..4429203-1458WP_107704128.1PLP-dependent aminotransferase family protein-
DAI21_RS214604429304..4430014+711WP_107704129.1GNAT family N-acetyltransferase-
DAI21_RS214654430011..4430151-141WP_005125190.1type B 50S ribosomal protein L36-
DAI21_RS214704430154..4430414-261WP_095281030.1type B 50S ribosomal protein L31-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8631.05 Da        Isoelectric Point: 8.9039

>T101361 WP_012016344.1 NZ_CP028520:4426204-4426422 [Lelliottia sp. WB101]
MSDKPLTKTDYLMRLRRCQSLDTLERVIEKNKYELPDHELAVFYSAADHRLAELTMNKLYDKIPVSVWKFVR

Download         Length: 219 bp

>T101361 NZ_CP028520:4426204-4426422 [Lelliottia sp. WB101]
ATGTCTGATAAACCATTAACAAAGACAGATTATTTGATGCGCTTGCGACGCTGCCAGTCACTGGACACCCTGGAGCGTGT
TATTGAAAAGAATAAATATGAACTTCCCGATCATGAACTGGCTGTATTTTATTCAGCAGCCGACCACCGCCTTGCAGAGT
TAACGATGAATAAACTGTATGACAAAATCCCAGTATCTGTGTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14521.26 Da        Isoelectric Point: 5.1481

>AT101361 WP_100777374.1 NZ_CP028520:4425802-4426176 [Lelliottia sp. WB101]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFINASRANPVSHSC

Download         Length: 375 bp

>AT101361 NZ_CP028520:4425802-4426176 [Lelliottia sp. WB101]
ATGGACGAATACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTTAATGATCCGACCTCCGCAATCAATTTGCAGCTAAATGAACTCATAGAGC
ATATAGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAATTGATTGAGCAAATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGCAGTTACGGCATTAACACACAAGATTTGCAAAAATGGCGTAAATCGGGAAACCGCCT
ATTCCGTTGTTTCATCAACGCGAGCAGAGCTAACCCGGTCAGTCATTCATGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2S5C408

Antitoxin

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Source
ID
Structure
No matching records found

References