Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2244860..2245464 Replicon chromosome
Accession NZ_CP028491
Organism Carboxydocella thermautotrophica strain 019

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CFE_RS11315 Protein ID WP_078665312.1
Coordinates 2244860..2245210 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag CFE_RS11320 Protein ID WP_174183013.1
Coordinates 2245213..2245464 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFE_RS11295 2240903..2241604 - 702 WP_078665308.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
CFE_RS11300 2241618..2242553 - 936 WP_078665309.1 hypothetical protein -
CFE_RS11305 2242676..2244004 - 1329 WP_078665310.1 type I glutamate--ammonia ligase -
CFE_RS11310 2244210..2244785 - 576 WP_078665311.1 ANTAR domain-containing protein -
CFE_RS11315 2244860..2245210 - 351 WP_078665312.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CFE_RS11320 2245213..2245464 - 252 WP_174183013.1 ribbon-helix-helix protein, CopG family Antitoxin
CFE_RS11325 2245619..2246851 - 1233 WP_078665314.1 transposase -
CFE_RS11330 2246991..2248370 - 1380 WP_078665315.1 dihydrolipoyl dehydrogenase -
CFE_RS11335 2248580..2248954 + 375 WP_078665316.1 hypothetical protein -
CFE_RS11340 2248999..2249736 - 738 WP_078665317.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12816.84 Da        Isoelectric Point: 7.2058

>T101348 WP_078665312.1 NZ_CP028491:c2245210-2244860 [Carboxydocella thermautotrophica]
MRIRRGDIFYAELSPVVGSEQGGTRPVLVLQNDIGNQHSPTTIVAAITSQISKAKLPTHVEIKAKISGLEKDSVILLEQI
RTIDKSRLREKVSTLDEEIMEKVNRAIAISLGLEEI

Download         Length: 351 bp

>T101348 NZ_CP028491:c2245210-2244860 [Carboxydocella thermautotrophica]
ATGCGGATTCGCCGCGGTGATATCTTTTACGCAGAGCTTAGCCCGGTGGTGGGCTCAGAACAGGGCGGAACTCGACCAGT
TCTGGTCCTGCAAAATGATATTGGCAACCAGCATAGTCCCACCACCATAGTGGCGGCCATTACTTCCCAGATCAGTAAAG
CCAAACTCCCCACCCATGTGGAGATTAAAGCTAAAATCAGCGGTCTGGAAAAGGATTCTGTGATATTGCTGGAACAGATT
CGCACCATCGATAAAAGCCGGCTGAGGGAGAAAGTTAGTACTCTGGATGAGGAGATCATGGAAAAAGTTAACCGGGCTAT
TGCTATCAGCCTGGGGTTGGAAGAAATATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9476.89 Da        Isoelectric Point: 4.5960

>AT101348 WP_174183013.1 NZ_CP028491:c2245464-2245213 [Carboxydocella thermautotrophica]
MISLPDQLLAEVDGLASAEKLNRSQLFREAVQHYIAERKKRQIREQMIRGYMEMAPINLSLANEYMGLEVDGTLPLWQAA
EGE

Download         Length: 252 bp

>AT101348 NZ_CP028491:c2245464-2245213 [Carboxydocella thermautotrophica]
ATGATCAGCCTGCCCGATCAATTGCTGGCTGAGGTGGATGGTCTGGCTTCAGCGGAAAAACTGAACCGCAGCCAGTTATT
TCGTGAAGCTGTCCAGCACTATATAGCAGAACGAAAAAAACGGCAGATCAGGGAGCAAATGATCCGCGGCTATATGGAAA
TGGCCCCGATTAACCTGTCTCTGGCTAACGAGTATATGGGCCTGGAGGTCGATGGAACCCTTCCCCTGTGGCAAGCGGCA
GAGGGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References