Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ParE-CopA/ParE-RHH
Location 38823..39403 Replicon plasmid unnamed2
Accession NZ_CP028489
Organism Yersinia massiliensis strain GTA

Toxin (Protein)


Gene name parE Uniprot ID A0A0U1QT96
Locus tag DA391_RS24025 Protein ID WP_011988449.1
Coordinates 39101..39403 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name copA Uniprot ID A0A0U1QTB9
Locus tag DA391_RS24020 Protein ID WP_011988472.1
Coordinates 38823..39113 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DA391_RS23990 33976..34290 - 315 WP_011988450.1 conjugal transfer protein TrbD -
DA391_RS23995 34293..34673 - 381 WP_011988438.1 TrbC/VirB2 family protein -
DA391_RS24000 34686..35645 - 960 WP_108088403.1 P-type conjugative transfer ATPase TrbB -
DA391_RS24005 35804..36172 - 369 WP_108088386.1 transcriptional regulator -
DA391_RS24010 36749..36970 + 222 WP_108088387.1 hypothetical protein -
DA391_RS24015 36967..37878 + 912 WP_108088388.1 zeta toxin family protein -
DA391_RS24020 38823..39113 + 291 WP_011988472.1 CopG family transcriptional regulator Antitoxin
DA391_RS24025 39101..39403 + 303 WP_011988449.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DA391_RS24030 39683..40720 + 1038 WP_108088389.1 Replication protein -
DA391_RS24035 41758..42075 + 318 WP_108088390.1 protein kleE -
DA391_RS24040 42270..42575 + 306 WP_108088391.1 transcriptional regulator KorA -
DA391_RS24045 42572..43342 + 771 WP_108088392.1 ParA family protein -
DA391_RS24050 43339..44391 + 1053 WP_108088393.1 ParB/RepB/Spo0J family partition protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..57277 57277


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11494.30 Da        Isoelectric Point: 5.1546

>T101344 WP_011988449.1 NZ_CP028489:39101-39403 [Yersinia massiliensis]
VPRLIWTQEAIQDVDRLYKFLAEKNVEAARKAAKVILDETTKIEAFPEIGRPAEFINVYCRELLVPFGVSGYVVLYRYDG
QLTTILAVKHQFEAGYLPEF

Download         Length: 303 bp

>T101344 NZ_CP028489:39101-39403 [Yersinia massiliensis]
GTGCCACGTCTGATTTGGACTCAGGAGGCGATACAAGATGTAGATCGCCTCTATAAATTTTTAGCAGAGAAGAATGTAGA
AGCTGCAAGAAAAGCAGCAAAAGTAATTTTAGATGAAACTACTAAAATTGAGGCATTTCCTGAAATTGGACGACCCGCTG
AGTTTATAAATGTGTATTGCAGAGAGTTGTTAGTGCCGTTCGGTGTAAGTGGATATGTAGTGTTGTACCGATATGATGGC
CAACTAACCACTATCTTAGCTGTAAAACATCAGTTTGAAGCGGGGTATCTGCCAGAGTTTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11173.62 Da        Isoelectric Point: 6.7575

>AT101344 WP_011988472.1 NZ_CP028489:38823-39113 [Yersinia massiliensis]
MKTSSNTPVSVKIEPTIKARMERLGESRERTMHWLVTDAIKKYVEHEEKREELKEAAHKAWLSFQETGLHVSSEEANEWL
TSLSEGHYKEPPKCHV

Download         Length: 291 bp

>AT101344 NZ_CP028489:38823-39113 [Yersinia massiliensis]
ATGAAGACCTCTTCCAATACACCTGTATCAGTCAAGATTGAGCCAACTATTAAGGCTCGTATGGAACGTTTGGGTGAAAG
CCGTGAACGTACTATGCACTGGCTAGTTACAGATGCTATCAAGAAGTATGTTGAACATGAAGAGAAAAGAGAAGAGTTAA
AAGAGGCCGCTCATAAAGCTTGGCTATCCTTCCAAGAAACTGGCTTGCATGTTTCATCTGAAGAGGCCAATGAATGGCTC
ACCAGTTTGTCGGAGGGGCATTATAAGGAACCTCCTAAGTGCCACGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1QT96

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1QTB9

References