Detailed information of TA system TA101341

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parE-PrpA/CC2985(antitoxin)
• Location: 30126..30672
• Replicon: plasmid unnamed1
• Accession: NZ_CP028488
• Organism: Yersinia massiliensis strain GTA

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: DA391_RS23295
• Protein ID: WP_108088331.1
• Coordinates: 30376..30672 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PrpA
• Uniprot ID: -
• Locus tag: DA391_RS23290
• Protein ID: WP_088130853.1
• Coordinates: 30126..30389 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DA391_RS23275	26088..27908	+	1821	WP_088130856.1	ATP-binding protein	-
DA391_RS23280	28072..28266	+	195	WP_088130855.1	hypothetical protein	-
DA391_RS23285	28476..29807	-	1332	WP_088130854.1	hypothetical protein	-
DA391_RS23290	30126..30389	+	264	WP_088130853.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
DA391_RS23295	30376..30672	+	297	WP_108088331.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DA391_RS23300	30994..32193	+	1200	WP_088130852.1	AAA family ATPase	-
DA391_RS23305	32202..33170	+	969	WP_088130851.1	ParB/RepB/Spo0J family partition protein	-
DA391_RS23315	33620..34560	-	941	Protein_29	translesion error-prone DNA polymerase V subunit UmuC	-
DA391_RS23320	34713..35123	-	411	WP_088130874.1	translesion error-prone DNA polymerase V autoproteolytic subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..121622	121622

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• Antitoxin ParD (4-75)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11398.99 Da
• Isoelectric Point: 5.1100

>T101341 WP_108088331.1 NZ_CP028488:30376-30672 [Yersinia massiliensis]
MKEINLTPKAIDDLENIWLYGQVQFGVAKADEYVARFSEIFDILARHEIGTQRPELGENIYSLPIEKHVIFFVPSESSIT
VIRILNQSQDVNRHISWR

Nucleotide

• Length: 297 bp

>T101341 NZ_CP028488:30376-30672 [Yersinia massiliensis]
ATGAAAGAGATTAATCTGACACCGAAAGCAATTGATGATTTGGAAAATATTTGGCTTTATGGTCAGGTACAATTTGGTGT
AGCCAAGGCGGACGAATATGTCGCTCGCTTTTCTGAAATATTTGATATTTTGGCCAGACATGAAATTGGTACACAACGAC
CTGAGTTAGGTGAAAATATTTATTCACTCCCTATTGAGAAGCATGTGATTTTTTTCGTTCCTTCAGAGTCTTCTATCACT
GTAATTCGTATTCTTAATCAATCACAAGATGTAAATCGTCACATTTCTTGGCGATAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9992.19 Da
• Isoelectric Point: 4.6926

>AT101341 WP_088130853.1 NZ_CP028488:30126-30389 [Yersinia massiliensis]
MARTMTVDVGEELRDFIDSLVSAGDYRTQSEVLRDALRLLREKQAESHLQSLRDLLAEGVSSGTPETWSKDVFLQRIKER
VNLNERD

Nucleotide

• Length: 264 bp

>AT101341 NZ_CP028488:30126-30389 [Yersinia massiliensis]
ATGGCCAGGACAATGACAGTAGATGTTGGCGAGGAACTTCGCGACTTCATCGATTCGCTGGTTAGCGCAGGTGATTATAG
AACTCAAAGCGAAGTGCTCCGTGATGCTTTGCGTTTATTGCGTGAAAAGCAGGCTGAGTCCCATTTGCAATCATTACGGG
ACTTGTTGGCTGAAGGGGTGAGTAGCGGCACTCCAGAAACATGGAGTAAAGATGTATTCCTACAGCGAATAAAGGAAAGG
GTTAATCTGAATGAAAGAGATTAA